Literature DB >> 15033778

An age-associated decrease in the frequency of C4B*Q0 indicates that null alleles of complement may affect health or survival.

Gudmundur Jóhann Arason1, Sigurdur Bödvarsson, Sigurudr Thor Sigurdarson, Gardar Sigurdsson, Gudmundur Thorgeirsson, Sveinn Gudmundsson, Judit Kramer, Georg Füst.   

Abstract

We studied the distribution of complement C4, C3, and factor B allotypes in 423 healthy Icelandic subjects from 17 to 89 years of age. A marked decrease was observed in the carrier frequency of variant alleles of complement C4B (C4B(*)Q0) and C3 (C3(*)F). These results confirm our previous observations on Hungarian subjects and suggest a negative effect of C4B(*)Q0 on health or survival.

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Year:  2003        PMID： 15033778     DOI： 10.1196/annals.1299.091

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  5 in total

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Journal:  PLoS One       Date:  2016-12-19       Impact factor: 3.240

5.  Investigation of complement component C4 copy number variation in human longevity.

Authors:  Friederike Flachsbart; Amke Caliebe; Femke-Anouska Heinsen; Tom Hemming-Karlsen; Stefan Schreiber; Andre Franke; Almut Nebel
Journal:  PLoS One       Date:  2014-01-22       Impact factor: 3.240
  5 in total

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