Literature DB >> 15033749

The role of beta-glucuronidase in induction of apoptosis by genistein combined polysaccharide (GCP) in xenogeneic mice bearing human mammary cancer cells.

Lan Yuan1, Chihiro Wagatsuma, Buxiang Sun, Jung-Hwan Kim, Young-Joon Surh.   

Abstract

In order to reveal the mechanisms underlying genistein combined polysaccharide (GCP) inhibition of tumor proliferation, we investigated the effects of GCP on the growth of human breast cancer cells transplanted to athymic nude mice. We further investigated the metabolism of genistein and its association with the beta-glucuronidase activity in tumor and normal tissues.

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Year:  2003        PMID： 15033749     DOI： 10.1196/annals.1299.063

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  4 in total

1.  Overestimation of flavonoid aglycones as a result of the ex vivo deconjugation of glucuronides by the tissue β-glucuronidase.

Authors:  Qing-Yi Lu; Lifeng Zhang; Guido Eibl; Vay Liang W Go
Journal:  J Pharm Biomed Anal       Date:  2013-10-05       Impact factor: 3.935

2.  Effects of a high dose, aglycone-rich soy extract on prostate-specific antigen and serum isoflavone concentrations in men with localized prostate cancer.

Authors:  Ralph W deVere White; Alexander Tsodikov; Eschelle C Stapp; Stephanie E Soares; Hajime Fujii; Robert M Hackman
Journal:  Nutr Cancer       Date:  2010       Impact factor: 2.900

3.  WMJ-S-001, a novel aliphatic hydroxamate derivative, exhibits anti-angiogenic activities via Src-homology-2-domain-containing protein tyrosine phosphatase 1.

Authors:  Yi-Fang Chang; Ya-Fen Hsu; Pei-Ting Chiu; Wei-Jan Huang; Shiu-Wen Huang; George Ou; Joen-Rong Sheu; Ming-Jen Hsu
Journal:  Oncotarget       Date:  2015-01-01

4.  Anti-cancer activity of an osthole derivative, NBM-T-BMX-OS01: targeting vascular endothelial growth factor receptor signaling and angiogenesis.

Authors:  Hung-Yu Yang; Ya-Fen Hsu; Pei-Ting Chiu; Shiau-Jing Ho; Chi-Han Wang; Chih-Chin Chi; Yu-Han Huang; Cheng-Feng Lee; Ying-Shiuan Li; George Ou; Ming-Jen Hsu
Journal:  PLoS One       Date:  2013-11-27       Impact factor: 3.240
  4 in total

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