Literature DB >> 15033739

1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) induces apoptosis in human neuroblastoma cell lines.

Ravi Shankar Akundi1, Michael Hüll, Hans Willi Clement, Bernd L Fiebich.   

Abstract

The former popular hypnotic chloral hydrate has been known to spontaneously condense with tryptamine in the body to give rise to a highly unpolar 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) derivative. Earlier studies have revealed the relative permeability of the molecule through the body, and its ability to induce Parkinson-like symptoms in rats. In this study, we report that TaClo is a highly cytotoxic agent that leads to apoptosis in human neuroblastoma cells involving caspase-3 activation.

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Year:  2003        PMID： 15033739     DOI： 10.1196/annals.1299.053

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  4 in total

1.  1-Trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) Alters Cell Cycle Progression in Human Neuroblastoma Cell Lines.

Authors:  Rakesh Kumar Sharma; Eduardo Candelario-Jalil; Doris Feineis; Gerhard Bringmann; Bernd L Fiebich; Ravi Shankar Akundi
Journal:  Neurotox Res       Date:  2017-07-18       Impact factor: 3.911

2.  Serine racemase regulated by binding to stargazin and PSD-95: potential N-methyl-D-aspartate-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (NMDA-AMPA) glutamate neurotransmission cross-talk.

Authors:  Ting Martin Ma; Bindu D Paul; Chenglai Fu; Shaohui Hu; Heng Zhu; Seth Blackshaw; Herman Wolosker; Solomon H Snyder
Journal:  J Biol Chem       Date:  2014-08-27       Impact factor: 5.157

3.  Excitotoxicity effects of glutamate on human neuroblastoma SH-SY5Y cells via oxidative damage.

Authors:  Zhong-Wei Sun; Lan Zhang; Shu-Jia Zhu; Wen-Chun Chen; Bing Mei
Journal:  Neurosci Bull       Date:  2010-02       Impact factor: 5.203

Review 4.  Researching glutamate - induced cytotoxicity in different cell lines: a comparative/collective analysis/study.

Authors:  Aristeidis A Kritis; Eleni G Stamoula; Krystallenia A Paniskaki; Theofanis D Vavilis
Journal:  Front Cell Neurosci       Date:  2015-03-17       Impact factor: 5.505
  4 in total

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