Literature DB >> 15033561

Sequence determination of the Crimean-Congo hemorrhagic fever virus L segment.

Erin Kinsella1, Sandra G Martin, Allen Grolla, Markus Czub, Heinz Feldmann, Ramon Flick.   

Abstract

Crimean-Congo hemorrhagic fever (CCHF) virus is highly pathogenic for humans and remains the only Category A virus for which full sequence information is currently unavailable. In this study we completed CCHF genome characterization by determining the L segment sequence using Dugbe and CCHF virus-specific oligonucleotides. Sequence alignments revealed the presence of four previously described conserved regions in all Bunyaviridae polymerases. Interestingly, additional regions containing putative Ovarian Tumor (OTU)-like cysteine protease and helicase domains were identified in the L segments of CCHF and Dugbe viruses, suggesting an autoproteolytic cleavage process for nairovirus L proteins.

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Year:  2004        PMID： 15033561     DOI： 10.1016/j.virol.2003.09.046

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  44 in total

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