Literature DB >> 15033437

The vanilloid receptor-1 (TRPV1) is expressed in some rat dorsal horn NK1 cells.

Stéphane Doly1, Jacqueline Fischer, Marie Conrath.   

Abstract

The vanilloid receptor-1 (TRPV1), the capsaicin receptor, a transducer of several nociceptive stimuli, is principally expressed by nociceptive fibers that specifically target supraspinal-projecting neurons expressing the NK1 receptor. TRPV1 is also expressed by intraspinal neurons. Using double immunocytochemistry, we show that 14.2% of these TRPV1 dorsal horn cell bodies also express the NK1 receptor suggesting that endogenous vanilloids may directly modulate second-order ascending neurons.

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Year:  2004        PMID： 15033437     DOI： 10.1016/j.brainres.2004.01.023

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  7 in total

1.  A novel method to quantify histochemical changes throughout the mediolateral axis of the substantia gelatinosa after spared nerve injury: characterization with TRPV1 and substance P.

Authors:  Gregory Corder; Andrew Siegel; Allison B Intondi; Xing Zhang; James E Zadina; Bradley K Taylor
Journal:  J Pain       Date:  2010-04       Impact factor: 5.820

2.  Persistent Nociception Triggered by Nerve Growth Factor (NGF) Is Mediated by TRPV1 and Oxidative Mechanisms.

Authors:  Michael A Eskander; Shivani Ruparel; Dustin P Green; Paul B Chen; Elaine D Por; Nathaniel A Jeske; Xiaoli Gao; Eric R Flores; Kenneth M Hargreaves
Journal:  J Neurosci       Date:  2015-06-03       Impact factor: 6.167

Review 3.  Unravelling the mystery of capsaicin: a tool to understand and treat pain.

Authors:  Jessica O'Neill; Christina Brock; Anne Estrup Olesen; Trine Andresen; Matias Nilsson; Anthony H Dickenson
Journal:  Pharmacol Rev       Date:  2012-10       Impact factor: 25.468

4.  Differential effects of peripheral versus central coadministration of QX-314 and capsaicin on neuropathic pain in rats.

Authors:  Jun Shen; Lyle E Fox; Jianguo Cheng
Journal:  Anesthesiology       Date:  2012-08       Impact factor: 7.892

5.  Axotomy of tributaries of the pelvic and pudendal nerves induces changes in the neurochemistry of mouse dorsal root ganglion neurons and the spinal cord.

Authors:  Carly J McCarthy; Eugenia Tomasella; Mariana Malet; Kim B Seroogy; Tomas Hökfelt; Marcelo J Villar; G F Gebhart; Pablo R Brumovsky
Journal:  Brain Struct Funct       Date:  2015-03-07       Impact factor: 3.270

Review 6.  Spinal Circuits for Touch, Pain, and Itch.

Authors:  Stephanie C Koch; David Acton; Martyn Goulding
Journal:  Annu Rev Physiol       Date:  2017-09-27       Impact factor: 19.318

7.  Central activation of TRPV1 and TRPA1 by novel endogenous agonists contributes to mechanical allodynia and thermal hyperalgesia after burn injury.

Authors:  Dustin Green; Shivani Ruparel; Xiaoli Gao; Nikita Ruparel; Mayur Patil; Armen Akopian; Kenneth Hargreaves
Journal:  Mol Pain       Date:  2016-07-12       Impact factor: 3.395
  7 in total

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