| Literature DB >> 15033304 |
T Kunath1, D Strumpf, J Rossant.
Abstract
The first priority of a mammalian embryo is to establish an intimate relationship with its mother. This is accomplished by precocious differentiation of the trophoblast lineage, which mediates uterine implantation and initiates the process of placentation. Surprisingly little is known about the molecular mechanisms that drive trophectoderm differentiation from the equipotent blastomeres of the morula. Somewhat more is known about the maintenance of trophoblast stem cells, once this lineage has been established. The first half of this review will focus on determination of the mouse trophoblast lineage and the second half will discuss the maintenance of trophoblast stem cells.Entities:
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Year: 2004 PMID： 15033304 DOI： 10.1016/j.placenta.2004.01.015
Source DB: PubMed Journal: Placenta ISSN： 0143-4004 Impact factor: 3.481