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Literature DB >> 15033291

Involvement of N-methyl-d-aspartate (NMDA) receptors in a rat model of visceral hypersensitivity.

Geneviève-Anne Gaudreau¹, Victor Plourde.

Abstract

N-Methyl-d-aspartate (NMDA) is known to be involved in the transmission of nociceptive information. In the present study, we investigated the effect of peripheral and central NMDA receptor antagonist MK-801 in visceral hypersensitivity. In an animal model of colorectal distension (CRD), administration of both intrathecal MK-801 (1.5 nmol) and intraperitoneal MK-801 (0.15 mg/kg) completely abolished the CRD-induced visceral hypersensitivity of noxious and innocuous stimuli. Thus, the results from this experiment demonstrate the efficacy of MK-801 in blocking the visceral hypersensitivity mediated by central and peripheral mechanisms.

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Year: 2004 PMID： 15033291 DOI： 10.1016/j.bbr.2003.07.004

Source DB: PubMed Journal: Behav Brain Res ISSN： 0166-4328 Impact factor: 3.332

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Cited

20 in total

1. Vagotomy upregulates expression of the N-methyl-D-aspartate receptor NR2D subunit in the stomach.

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Journal: J Gastroenterol Date: 2008-07-01 Impact factor: 7.527

2. Colorectal distention induces acute and delayed visceral hypersensitivity: role of peripheral corticotropin-releasing factor and interleukin-1 in rats.

Authors: Tsukasa Nozu; Shima Kumei; Saori Miyagishi; Kaoru Takakusaki; Toshikatsu Okumura
Journal: J Gastroenterol Date: 2015-03-26 Impact factor: 7.527

Review 3. The use of non-narcotic pain medication in pediatric gastroenterology.

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4. Expression of vesicular glutamate transporters type 1 and 2 in sensory and autonomic neurons innervating the mouse colorectum.

Authors: Pablo R Brumovsky; David R Robinson; Jun-Ho La; Kim B Seroogy; Kerstin H Lundgren; Kathryn M Albers; Michael E Kiyatkin; Rebecca P Seal; Robert H Edwards; Masahiko Watanabe; Tomas Hökfelt; G F Gebhart
Journal: J Comp Neurol Date: 2011-11-01 Impact factor: 3.215

5. Role of astrocytes and altered regulation of spinal glutamatergic neurotransmission in stress-induced visceral hyperalgesia in rats.

Authors: Sylvie Bradesi; Viktoriya Golovatscka; Helena S Ennes; James A McRoberts; Iordanes Karagiannides; Iordanes Karagiannidis; Kyriaki Bakirtzi; Charalabos Pothoulakis; Emeran A Mayer
Journal: Am J Physiol Gastrointest Liver Physiol Date: 2011-06-30 Impact factor: 4.052

10. NMDA receptor subunit expression and PAR2 receptor activation in colospinal afferent neurons (CANs) during inflammation induced visceral hypersensitivity.

Authors: Shelby K Suckow; Robert M Caudle
Journal: Mol Pain Date: 2009-09-22 Impact factor: 3.395

Involvement of N-methyl-d-aspartate (NMDA) receptors in a rat model of visceral hypersensitivity.

1. Vagotomy upregulates expression of the N-methyl-D-aspartate receptor NR2D subunit in the stomach.

2. Colorectal distention induces acute and delayed visceral hypersensitivity: role of peripheral corticotropin-releasing factor and interleukin-1 in rats.

Review 3. The use of non-narcotic pain medication in pediatric gastroenterology.

4. Expression of vesicular glutamate transporters type 1 and 2 in sensory and autonomic neurons innervating the mouse colorectum.

5. Role of astrocytes and altered regulation of spinal glutamatergic neurotransmission in stress-induced visceral hyperalgesia in rats.

Review 6. Visceral pain: the neurophysiological mechanism.

Review 7. Acupuncture-moxibustion in treating irritable bowel syndrome: how does it work?

8. NMDA receptor mediates chronic visceral pain induced by neonatal noxious somatic stimulation.

9. Expression of the N-methyl-D-aspartate receptor NR1 splice variants and NR2 subunit subtypes in the rat colon.

10. NMDA receptor subunit expression and PAR2 receptor activation in colospinal afferent neurons (CANs) during inflammation induced visceral hypersensitivity.