Literature DB >> 15032911

Aromatase immunolocalization in human ductuli efferentes and proximal ductus epididymis.

A Carpino1, F Romeo, V Rago.   

Abstract

Abstract Cytochrome P450 aromatase is a terminal enzyme that catalyses the conversion of androgens into oestrogens. This study investigated the immunohistochemical localization of aromatase in human efferent ductules and proximal ductus epididymis using a mouse anti-human monoclonal P450arom IgG as primary antibody and a goat anti-mouse biotinylated IgG as secondary antibody. A strong immunoreaction was observed in the epithelial cell cytoplasm of both ductuli efferentes and proximal ductus epididymis, whereas the smooth muscle cells were immunonegative in the two regions. The results show, for the first time in humans, that epithelial cells of ductuli efferentes and proximal caput epididymis express aromatase, suggesting that locally produced oestrogens may have a role in epididymal function.

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Year:  2004        PMID： 15032911      PMCID： PMC1571251          DOI： 10.1111/j.0021-8782.2004.00272.x

Source DB:  PubMed          Journal:  J Anat        ISSN： 0021-8782            Impact factor:   2.610


  28 in total

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  12 in total

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