Literature DB >> 15032672

Kinase chemogenomics: targeting the human kinome for target validation and drug discovery.

E ter Haar1, W P Walters, S Pazhanisamy, P Taslimi, A C Pierce, G W Bemis, F G Salituro, S L Harbeson.   

Abstract

Chemogenomics is a gene family-based approach to drug discovery and target validation. This review will summarize the application of this interdisciplinary approach to the protein kinases of the human genome with emphasis upon the synergies and efficiencies to be gained. Specific examples from the SAPK-family will be discussed.

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Year:  2004        PMID： 15032672     DOI： 10.2174/1389557043487367

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  3 in total

Review 1.  Deciphering the roles of glycogen synthase kinase 3 (GSK3) in the treatment of autism spectrum disorder and related syndromes.

Authors:  Mahdi Rizk; Zahraa Saker; Hisham F Bahmad; Sanaa Nabha; Hayat Harati; Youssef Fares
Journal:  Mol Biol Rep       Date:  2021-03-01       Impact factor: 2.316

2.  Unprecedently Large-Scale Kinase Inhibitor Set Enabling the Accurate Prediction of Compound-Kinase Activities: A Way toward Selective Promiscuity by Design?

Authors:  Serge Christmann-Franck; Gerard J P van Westen; George Papadatos; Fanny Beltran Escudie; Alexander Roberts; John P Overington; Daniel Domine
Journal:  J Chem Inf Model       Date:  2016-08-11       Impact factor: 4.956

Review 3.  Cdc-Like Kinases (CLKs): Biology, Chemical Probes, and Therapeutic Potential.

Authors:  Paula Martín Moyano; Václav Němec; Kamil Paruch
Journal:  Int J Mol Sci       Date:  2020-10-13       Impact factor: 5.923
  3 in total

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