Literature DB >> 15031494

Organic chemistry in drug discovery.

Malcolm MacCoss1, Thomas A Baillie.   

Abstract

The role played by organic chemistry in the pharmaceutical industry continues to be one of the main drivers in the drug discovery process. However, the precise nature of that role is undergoing a visible change, not only because of the new synthetic methods and technologies now available to the synthetic and medicinal chemist, but also in several key areas, particularly in drug metabolism and chemical toxicology, as chemists deal with the ever more rapid turnaround of testing data that influences their day-to-day decisions.

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Year:  2004        PMID: 15031494     DOI: 10.1126/science.1096800

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  12 in total

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4.  Rapid and quantitative measurement of metabolic stability without chromatography or mass spectrometry.

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5.  Preparation and biological evaluation of synthetic and polymer-encapsulated congeners of the antitumor agent pactamycin: insight into functional group effects and biological activity.

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Review 6.  New paradigms in GPCR drug discovery.

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Review 7.  Dimeric pyrrole-imidazole alkaloids: synthetic approaches and biosynthetic hypotheses.

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8.  Drug Discovery, CAM and Natural Products.

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9.  Synthesis of Polycyclic Ether-Benzopyrans and In Vitro Inhibitory Activity against Leishmania tarentolae.

Authors:  Sarita Singh; Jacob P Grabowski; Shilpa Pohani; C Fiore Apuzzo; David C Platt; Marjorie A Jones; T Andrew Mitchell
Journal:  Molecules       Date:  2020-11-21       Impact factor: 4.411

10.  Ion channels as drug targets: the next GPCRs.

Authors:  Gregory J Kaczorowski; Owen B McManus; Birgit T Priest; Maria L Garcia
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