Literature DB >> 15030767

Unraveling the NALP-3/IL-1beta inflammasome: a big lesson from a small mutation.

Charles A Dinarello1.   

Abstract

Cytokine-mediated inflammation is a target for novel therapies as well as for fundamental research. A single amino acid mutation in the NALP-3 gene controlling the activation of caspase-1 results in increased processing of the inactive IL-1beta precursor and release of the active cytokine. Blocking IL-1 receptors arrests inflammation in humans with the mutation.

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Year:  2004        PMID： 15030767     DOI： 10.1016/s1074-7613(04)00055-x

Source DB:  PubMed          Journal:  Immunity        ISSN： 1074-7613            Impact factor:   31.745


  11 in total

1.  Caspase recruitment domain-containing protein 8 (CARD8) negatively regulates NOD2-mediated signaling.

Authors:  Oliver von Kampen; Simone Lipinski; Andreas Till; Seamus J Martin; Wilfried Nietfeld; Hans Lehrach; Stefan Schreiber; Philip Rosenstiel
Journal:  J Biol Chem       Date:  2010-04-12       Impact factor: 5.157

Review 2.  Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1beta generation.

Authors:  L Ferrero-Miliani; O H Nielsen; P S Andersen; S E Girardin
Journal:  Clin Exp Immunol       Date:  2007-02       Impact factor: 4.330

3.  Genetic variation in inflammasome genes is associated with outcome in bacterial meningitis.

Authors:  Madelijn Geldhoff; Barry B Mook-Kanamori; Matthijs C Brouwer; Mercedes Valls Seron; Frank Baas; Arie van der Ende; Diederik van de Beek
Journal:  Immunogenetics       Date:  2012-09-30       Impact factor: 2.846

4.  P2X(7) receptor at the heart of disease.

Authors:  Ei Vasileiou; R M Montero; C M Turner; G Vergoulas
Journal:  Hippokratia       Date:  2010-07       Impact factor: 0.471

5.  Early efficacy trial of anakinra in corticosteroid-resistant autoimmune inner ear disease.

Authors:  Andrea Vambutas; Martin Lesser; Virginia Mullooly; Shresh Pathak; Gerald Zahtz; Lisa Rosen; Elliot Goldofsky
Journal:  J Clin Invest       Date:  2014-08-18       Impact factor: 14.808

6.  Tyrosine kinase 2 controls IL-1ß production at the translational level.

Authors:  Marta Radwan; Rita Stiefvater; Tom Grunert; Omar Sharif; Ingrid Miller; Martina Marchetti-Deschmann; Günter Allmaier; Manfred Gemeiner; Sylvia Knapp; Pavel Kovarik; Mathias Müller; Birgit Strobl
Journal:  J Immunol       Date:  2010-08-16       Impact factor: 5.422

7.  A Role for the Inflammasome in Spontaneous Labor at Term.

Authors:  Roberto Romero; Yi Xu; Olesya Plazyo; Piya Chaemsaithong; Tinnakorn Chaiworapongsa; Ronald Unkel; Nandor Gabor Than; Po Jen Chiang; Zhong Dong; Zhonghui Xu; Adi L Tarca; Vikki M Abrahams; Sonia S Hassan; Lami Yeo; Nardhy Gomez-Lopez
Journal:  Am J Reprod Immunol       Date:  2016-03-08       Impact factor: 3.886

8.  Effect of anakinra on arthropathy in CINCA/NOMID syndrome.

Authors:  Takako Miyamae; Yutaka Inaba; Gen Nishimura; Masako Kikuchi; Takayuki Kishi; Ryoki Hara; Utako Kaneko; Toshihiko Shinoki; Tomoyuki Imagawa; Shumpei Yokokta
Journal:  Pediatr Rheumatol Online J       Date:  2010-03-16       Impact factor: 3.054

9.  P2X7R activation drives distinct IL-1 responses in dendritic cells compared to macrophages.

Authors:  Pavlos C Englezou; Simon W Rothwell; Joseph S Ainscough; David Brough; Robert Landsiedel; Alexei Verkhratsky; Ian Kimber; Rebecca J Dearman
Journal:  Cytokine       Date:  2015-06-09       Impact factor: 3.861

10.  In vivo regulation of interleukin 1beta in patients with cryopyrin-associated periodic syndromes.

Authors:  Helen J Lachmann; Philip Lowe; Sandra Daniela Felix; Christiane Rordorf; Kieron Leslie; Sheril Madhoo; Helmut Wittkowski; Stephan Bek; Nicole Hartmann; Sophie Bosset; Philip N Hawkins; Thomas Jung
Journal:  J Exp Med       Date:  2009-04-13       Impact factor: 14.307
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