| Literature DB >> 15028243 |
Joanna S Fowler1, Jean Logan, Gene-Jack Wang, Nora D Volkow, Frank Telang, Yu-Shin Ding, Colleen Shea, Victor Garza, Youwen Xu, Zizhong Li, David Alexoff, Paul Vaska, Richard Ferrieri, David Schlyer, Wei Zhu, S John Gatley.
Abstract
The monoamine oxidase A and B (MAO A and B) radiotracers [(11)C]clorgyline (CLG) and [(11)C]L-deprenyl (DEP) and their deuterium labeled counterparts (CLG-D and DEP-D) were compared to determine whether their distribution and kinetics in humans are consistent with their physical, chemical and pharmacological properties and the reported ratios of MAO A:MAO B in post-mortem human tissues. Irreversible binding was consistently higher for DEP in brain, heart, kidneys and spleen but not lung where CLG >DEP and not in thyroid where there is no DEP binding. The generally higher DEP binding is consistent with its higher enzyme affinity and larger free fraction in plasma while differences in regional distribution for CLG and DEP in brain, heart, thyroid and lungs are consistent with different relative ratios of MAO A and B in humans.Entities:
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Year: 2004 PMID： 15028243 DOI： 10.1016/j.nucmedbio.2003.10.003
Source DB: PubMed Journal: Nucl Med Biol ISSN： 0969-8051 Impact factor: 2.408