Literature DB >> 15027897

CD4+ CD25+ Treg: divide and rule?

Lucy S K Walker1.   

Abstract

Research on CD4+ CD25+ regulatory T cells (Treg) has gathered momentum over the last five years but many aspects of their fundamental biology remain elusive. Treg have been considered to be 'naturally anergic' based on their failure to proliferate in response to T-cell receptor ligation in vitro. Several recent studies challenge this view and demonstrate a robust proliferative capacity for CD25+ cells. The significance of this finding for Treg homeostasis and function is considered below.

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Year:  2004        PMID： 15027897      PMCID： PMC1782405          DOI： 10.1111/j.0019-2805.2003.01788.x

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  84 in total

1.  Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide.

Authors:  M S Jordan; A Boesteanu; A J Reed; A L Petrone; A E Holenbeck; M A Lerman; A Naji; A J Caton
Journal:  Nat Immunol       Date:  2001-04       Impact factor: 25.606

2.  IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo.

Authors:  M Hara; C I Kingsley; M Niimi; S Read; S E Turvey; A R Bushell; P J Morris; F Powrie; K J Wood
Journal:  J Immunol       Date:  2001-03-15       Impact factor: 5.422

3.  CD25+ CD4+ T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10.

Authors:  O Annacker; R Pimenta-Araujo; O Burlen-Defranoux; T C Barbosa; A Cumano; A Bandeira
Journal:  J Immunol       Date:  2001-03-01       Impact factor: 5.422

4.  CD4+CD25+ regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells.

Authors:  L Cederbom; H Hall; F Ivars
Journal:  Eur J Immunol       Date:  2000-06       Impact factor: 5.532

5.  Repertoire requirements of CD4+ T cells that prevent spontaneous autoimmune encephalomyelitis.

Authors:  D Olivares-Villagómez; A K Wensky; Y Wang; J J Lafaille
Journal:  J Immunol       Date:  2000-05-15       Impact factor: 5.422

6.  CD25 is a marker for CD4+ thymocytes that prevent autoimmune diabetes in rats, but peripheral T cells with this function are found in both CD25+ and CD25- subpopulations.

Authors:  L A Stephens; D Mason
Journal:  J Immunol       Date:  2000-09-15       Impact factor: 5.422

7.  Naturally anergic and suppressive CD25(+)CD4(+) T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation.

Authors:  Y Kuniyasu; T Takahashi; M Itoh; J Shimizu; G Toda; S Sakaguchi
Journal:  Int Immunol       Date:  2000-08       Impact factor: 4.823

8.  Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells.

Authors:  H Jonuleit; E Schmitt; G Schuler; J Knop; A H Enk
Journal:  J Exp Med       Date:  2000-11-06       Impact factor: 14.307

9.  Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation.

Authors:  S Read; V Malmström; F Powrie
Journal:  J Exp Med       Date:  2000-07-17       Impact factor: 14.307

10.  Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.

Authors:  T Takahashi; T Tagami; S Yamazaki; T Uede; J Shimizu; N Sakaguchi; T W Mak; S Sakaguchi
Journal:  J Exp Med       Date:  2000-07-17       Impact factor: 14.307
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  25 in total

1.  Oestradiol potentiates the suppressive function of human CD4 CD25 regulatory T cells by promoting their proliferation.

Authors:  G Aleph Prieto; Yvonne Rosenstein
Journal:  Immunology       Date:  2006-05       Impact factor: 7.397

2.  Naturally occurring and inducible T-regulatory cells modulating immune response in allergic asthma.

Authors:  Halvor S McGee; Devendra K Agrawal
Journal:  Am J Respir Crit Care Med       Date:  2009-05-15       Impact factor: 21.405

3.  T regulatory cell mediated immunotherapy for solid organ transplantation: A clinical perspective.

Authors:  Mohammad Afzal Khan
Journal:  Mol Med       Date:  2016-11-22       Impact factor: 6.354

4.  Treg/Th17 imbalance is associated with cardiovascular complications in uremic patients undergoing maintenance hemodialysis.

Authors:  Danyan Chen; Xiaolong Huang; Song Lu; Hua Gan; Weixue Tang; Ke Liu
Journal:  Biomed Rep       Date:  2013-01-31

5.  Cytokine and chemokine responses associated with clearance of a primary Salmonella enterica serovar Typhimurium infection in the chicken and in protective immunity to rechallenge.

Authors:  G S K Withanage; Paul Wigley; Pete Kaiser; Pietro Mastroeni; Heather Brooks; Claire Powers; Richard Beal; Paul Barrow; Duncan Maskell; Ian McConnell
Journal:  Infect Immun       Date:  2005-08       Impact factor: 3.441

6.  Combination peptide immunotherapy suppresses antibody and helper T-cell responses to the RhD protein in HLA-transgenic mice.

Authors:  Lindsay S Hall; Andrew M Hall; Wendy Pickford; Mark A Vickers; Stanislaw J Urbaniak; Robert N Barker
Journal:  Haematologica       Date:  2014-01-17       Impact factor: 9.941

7.  Preferential feline immunodeficiency virus (FIV) infection of CD4+ CD25+ T-regulatory cells correlates both with surface expression of CXCR4 and activation of FIV long terminal repeat binding cellular transcriptional factors.

Authors:  Anjali Joshi; Himanshu Garg; Mary B Tompkins; Wayne A Tompkins
Journal:  J Virol       Date:  2005-04       Impact factor: 5.103

8.  TLR2/6 stimulation of the rat lung: effects on lymphocyte subsets, natural killer cells and dendritic cells in different parts of the air-conducting compartments and at different ages.

Authors:  Reinhard Pabst; Deniz Durak; Anna Roos; Anke Lührmann; Thomas Tschernig
Journal:  Immunology       Date:  2008-06-19       Impact factor: 7.397

Review 9.  Regulatory T cells overturned: the effectors fight back.

Authors:  Lucy S K Walker
Journal:  Immunology       Date:  2009-04       Impact factor: 7.397

10.  Investigation of memory responses following Plasmodium chabaudi AS infection in mice distinct in susceptibility to clinical malaria.

Authors:  Jiraprapa Wipasa; Panida Hemsokana; Tunlaya Ruankham; Surat Hongsibsong
Journal:  Parasitol Res       Date:  2009-12       Impact factor: 2.289
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