| Literature DB >> 15026870 |
Daniel Petrovic1, Dejan Bregar, Barbara Guzic-Salobir, Erik Skof, Matjaz Span, Rifet Terzić, Mojca Globocnik Petrovic, Irena Keber, Mitja Letonja, Marjeta Zorc, Matej Podbregar, Borut Peterlin.
Abstract
In this association study the authors compared the insertion/deletion (I/D) angiotensin-I converting enzyme (ACE) gene polymorphism in females and males with premature myocardial infarction (MI). I/D ACE gene polymorphism was tested in 738 subjects: 302 patients with MI (151 men and 151 women) and 436 healthy subjects (207 men and 229 women). In women the ACE-DD genotype was not associated with MI (OR 1.1, 95% CI 0.6-2.1, p=0.6), whereas the ACE-DD genotype conferred a 2-fold independent risk for MI in men (95% CI=1.2-3.4; p=0.013) after adjustment for cardiovascular risk factors. The authors found evidence for the sex difference in the effect of the ACE-DD genotype on MI risk. The ACE-DD genotype conferred a 2-fold independent risk for premature MI in males.Entities:
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Year: 2004 PMID： 15026870 DOI： 10.1177/000331970405500207
Source DB: PubMed Journal: Angiology ISSN： 0003-3197 Impact factor: 3.619