| Literature DB >> 15026065 |
Joo Hyun Moh1, Young Hoon Choi, Kyoung Min Lim, Ki-Wha Lee, Song Seok Shin, Jin Kyu Choi, Hyun Joo Koh, Shin Chung.
Abstract
2,2-dimethyl-4-phenyl-5-[4-(methylsulfinyl)phenyl]-3(2H)furanone derivatives, 3 and 6, were shown to be effectively transformed in vivo into the corresponding methylsulfone derivatives 1 and 4, when orally administered to rats. Pharmacological implications for use of sulfoxide analogues 3 and 6 are discussed as prodrugs to potent selective COX-2 inhibitors 1 and 4.Entities:
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Year: 2004 PMID： 15026065 DOI： 10.1016/j.bmcl.2004.01.048
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823