| Literature DB >> 15026056 |
Tao Guo1, Anton E P Adang, Roland E Dolle, Guizhen Dong, Dan Fitzpatrick, Peng Geng, Koc-Kan Ho, Steven G Kultgen, Ruiyan Liu, Edward McDonald, Brian F McGuinness, Kurt W Saionz, Kenneth J Valenzano, Nicole C R van Straten, Dan Xie, Maria L Webb.
Abstract
High-throughput screening of two million compounds in 37 distinct encoded combinatorial libraries using FSH receptor transfected cells provided small molecule agonists such as 1 (EC(50)=3 microM) and 2 (EC(50)=3.9 microM), based on which a focused combinatorial library with a total of 31372 compounds was designed, synthesized, and screened to reveal 72 novel biaryl FSH receptor agonists such as 8a-c as well as a unique combinatorial SAR.Entities:
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Year: 2004 PMID： 15026056 DOI： 10.1016/j.bmcl.2004.01.042
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823