| Literature DB >> 15026037 |
Annie Mayence1, Jean Jacques Vanden Eynde, Tien L Huang.
Abstract
Infrared and colorimetry data suggest that bisbenzamidines connected by various rigid or flexible linkers are able to interact with heme in cell-free systems. At pH 5.0 the inhibition of formation of beta-hematin could be ascertained by infrared spectroscopy whereas at pH 7.0 the interaction yielded insoluble complexes for which a sandwich-type structure of stoichiometry 2:1, heme-drug, is tentatively proposed.Entities:
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Year: 2004 PMID： 15026037 DOI： 10.1016/j.bmcl.2004.01.070
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823