| Literature DB >> 15026026 |
Elba V M Maciel1, Vanduir S Araújo-Filho, Mineo Nakazawa, Yara M Gomes, Luana C B B Coelho, Maria T S Correia.
Abstract
The mitogenic effect of Cratylia mollis seed lectin preparations containing two (Cramoll 1,4) or one molecular form (Cramoll 1) showed activity similar to the well known T-cell mitogen, concanavalin A (Con A). The effect on human lymphocytes was analyzed through a colorimetric assay using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT). Inhibition of lymphocyte proliferation with methyl-alpha-d-mannoside (both preparations) indicated that the mitogenic effect involved carbohydrate lectin binding sites.Entities:
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Year: 2004 PMID： 15026026 DOI： 10.1016/j.biologicals.2003.12.001
Source DB: PubMed Journal: Biologicals ISSN： 1045-1056 Impact factor: 1.856