| Literature DB >> 15023463 |
Luana Perioli1, Valeria Ambrogi, Daniela Rubini, Stefano Giovagnoli, Maurizio Ricci, Paolo Blasi, Carlo Rossi.
Abstract
Mucoadhesive tablets using different mixture of cellulose and polyacrylic derivatives were prepared in order to obtain new formulations containing metronidazole for periodontal disease treatment. All tablets were characterized by swelling studies, ex vivo and in vivo mucoadhesive time, ex vivo mucoadhesion force, in vitro and in vivo release. The best mucoadhesive performance and the best in vitro drug release profile were achieved by using hydroxyethyl cellulose (HEC) and carbomer 940 2:2 ratio. The chosen tablet, containing 20 mg of metronidazole, performed 12 h drug sustained release with buccal concentrations always higher than its MIC.Entities:
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Year: 2004 PMID： 15023463 DOI： 10.1016/j.jconrel.2003.12.018
Source DB: PubMed Journal: J Control Release ISSN： 0168-3659 Impact factor: 9.776