Literature DB >> 1502018

Studies on 2-n-propyl-2(E)-pentenoate (delta 2(E)-valproate) in man.

L Gram1.   

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Year:  1992        PMID： 1502018     DOI： 10.1007/bf01962709

Source DB:  PubMed          Journal:  Pharm Weekbl Sci        ISSN： 0167-6555


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  15 in total

1.  Transfer of valproic acid and its main active unsaturated metabolite to the gestational tissue: correlation with neural tube defect formation in the mouse.

Authors:  H Nau
Journal:  Teratology       Date:  1986-02

2.  Comparative evaluation of anticonvulsant and toxic potencies of valproic acid and 2-en-valproic acid in different animal models of epilepsy.

Authors:  W Löscher; H Nau; C Marescaux; M Vergnes
Journal:  Eur J Pharmacol       Date:  1984-03-23       Impact factor: 4.432

3.  Weight gain during treatment with valproate.

Authors:  H Dinesen; L Gram; T Andersen; M Dam
Journal:  Acta Neurol Scand       Date:  1984-08       Impact factor: 3.209

4.  Sodium valproate, serum level and clinical effect in epilepsy: a controlled study.

Authors:  L Gram; H Flachs; A Würtz-Jørgensen; J Parnas; B Andersen
Journal:  Epilepsia       Date:  1979-06       Impact factor: 5.864

5.  Distribution of valproic acid and its metabolites in various brain areas of dogs and rats after acute and prolonged treatment.

Authors:  W Löscher; H Nau
Journal:  J Pharmacol Exp Ther       Date:  1983-09       Impact factor: 4.030

6.  Penetration of valproate and its active metabolites into cerebrospinal fluid of children with epilepsy.

Authors:  W Löscher; H Nau; H Siemes
Journal:  Epilepsia       Date:  1988 May-Jun       Impact factor: 5.864

7.  Comparison of the pharmacological and biochemical profiles of valproic acid (VPA) and its cerebral metabolite (2-en-VPA) after oral administration in mice.

Authors:  P E Keane; J Simiand; M Morre
Journal:  Methods Find Exp Clin Pharmacol       Date:  1985-02

8.  Anticonvulsant activity of metabolites of valproic acid.

Authors:  W Löscher
Journal:  Arch Int Pharmacodyn Ther       Date:  1981-01

Review 9.  Pharmacological, toxicological and neurochemical effects of delta 2(E)-valproate in animals.

Authors:  W Löscher
Journal:  Pharm Weekbl Sci       Date:  1992-06-19

10.  Single-dose tolerance and pharmacokinetics of 2-n-propyl-2(E)-pentenoate (delta 2(E)-valproate) in healthy male volunteers.

Authors:  R H Düsing
Journal:  Pharm Weekbl Sci       Date:  1992-06-19
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