Literature DB >> 15020066

Protective DNA vaccination against experimental autoimmune encephalomyelitis is associated with induction of IFNbeta.

Judit Wefer1, Robert A Harris, Anna Lobell.   

Abstract

DNA vaccines encoding encephalitogenic peptides protect against subsequent development of rat experimental autoimmune encephalomyelitis (EAE) through unknown mechanisms. We investigated immune cell phenotypes at different time points after DNA vaccination with vaccine encoding myelin oligodendrocyte glycoprotein peptide 91-108 and subsequent induction of EAE. In protected rats, we observed (i) no alterations in antigen-specific Th2 or Th3 responses, (ii) reduced MHC II expression on splenocytes early after EAE induction, (iii) antigen-specific upregulation of IFNbeta upon recall stimulation and (iv) reduced IL-12Rbeta2 on lymphocytes. We suggest that the underlying mechanism of DNA vaccination is associated with immunomodulation exerted by induced IFNbeta.

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Year:  2004        PMID： 15020066     DOI： 10.1016/j.jneuroim.2003.12.012

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  8 in total

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Review 4.  Emerging immunopharmacological targets in multiple sclerosis.

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Journal:  J Neurol Sci       Date:  2015-09-14       Impact factor: 3.181

5.  Synergistic interaction between Toll-like receptor agonists is required for induction of experimental autoimmune encephalomyelitis in Lewis rats.

Authors:  Norbert A Wolf; Taba K Amouzegar; Robert H Swanborg
Journal:  J Neuroimmunol       Date:  2007-03-06       Impact factor: 3.478

6.  Treatment with MOG-DNA vaccines induces CD4+CD25+FoxP3+ regulatory T cells and up-regulates genes with neuroprotective functions in experimental autoimmune encephalomyelitis.

Authors:  Nicolás Fissolo; Carme Costa; Ramil N Nurtdinov; Marta F Bustamante; Victor Llombart; María J Mansilla; Carmen Espejo; Xavier Montalban; Manuel Comabella
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7.  Impaired autoimmune T helper 17 cell responses following DNA vaccination against rat experimental autoimmune encephalomyelitis.

Authors:  Asa Andersson; Magnus Isaksson; Judit Wefer; Anna Norling; Amilcar Flores-Morales; Fredrik Rorsman; Olle Kämpe; Robert A Harris; Anna Lobell
Journal:  PLoS One       Date:  2008-11-10       Impact factor: 3.240

8.  Tolerogenic β2-glycoprotein I DNA vaccine and FK506 as an adjuvant attenuates experimental obstetric antiphospholipid syndrome.

Authors:  Ya-Hsuan Chao; Der-Yuan Chen; Joung-Liang Lan; Kuo-Tung Tang; Chi-Chien Lin
Journal:  PLoS One       Date:  2018-06-12       Impact factor: 3.240
  8 in total

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