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Literature DB >> 15018947

Nogo and axon regeneration.

Abstract

Nogo-A is one of several neurite growth inhibitory components present in oligodendrocytes and CNS myelin membranes. Nogo has a crucial role in restricting axonal regeneration and compensatory fibre growth in the injured adult mammalian CNS. Recent studies have shown that in vivo applications of Nogo neutralizing antibodies, peptides blocking the Nogo receptor subunit NgR, or blockers of the postreceptor components Rho-A and ROCK induce long-distance axonal regeneration and compensatory sprouting, accompanied by an impressive enhancement of functional recovery, in the rat and mouse spinal cord.

Entities: Gene Species

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Year: 2004 PMID： 15018947 DOI： 10.1016/j.conb.2004.01.004

Source DB: PubMed Journal: Curr Opin Neurobiol ISSN： 0959-4388 Impact factor: 6.627

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Cited

173 in total

1. Crocetin Potentiates Neurite Growth in Hippocampal Neurons and Facilitates Functional Recovery in Rats with Spinal Cord Injury.

Authors: Xiqian Wang; Xiejia Jiao; Zhonghao Liu; Yixin Li
Journal: Neurosci Bull Date: 2017-08-02 Impact factor: 5.203

2. IT delivery of ChABC modulates NG2 and promotes GAP-43 axonal regrowth after spinal cord injury.

Authors: I Novotna; L Slovinska; I Vanicky; M Cizek; J Radonak; D Cizkova
Journal: Cell Mol Neurobiol Date: 2011-06-01 Impact factor: 5.046

3. Expression of a dominant-negative Rho-kinase promotes neurite outgrowth in a microenvironment mimicking injured central nervous system.

Authors: Ping Yang; Hui-zhong Wen; Jin-hai Zhang
Journal: Acta Pharmacol Sin Date: 2010-04-12 Impact factor: 6.150

4. How hard is the CNS hardware?

Authors: Martin E Schwab
Journal: Nat Neurosci Date: 2010-12 Impact factor: 24.884

Review 5. Failed central nervous system regeneration: a downside of immune privilege?

Authors: Ingo Bechmann
Journal: Neuromolecular Med Date: 2005 Impact factor: 3.843

6. Chronic enhancement of the intrinsic growth capacity of sensory neurons combined with the degradation of inhibitory proteoglycans allows functional regeneration of sensory axons through the dorsal root entry zone in the mammalian spinal cord.

Authors: Michael P Steinmetz; Kevin P Horn; Veronica J Tom; Jared H Miller; Sarah A Busch; Dileep Nair; Daniel J Silver; Jerry Silver
Journal: J Neurosci Date: 2005-08-31 Impact factor: 6.167

Nogo and axon regeneration.

1. Crocetin Potentiates Neurite Growth in Hippocampal Neurons and Facilitates Functional Recovery in Rats with Spinal Cord Injury.

2. IT delivery of ChABC modulates NG2 and promotes GAP-43 axonal regrowth after spinal cord injury.

3. Expression of a dominant-negative Rho-kinase promotes neurite outgrowth in a microenvironment mimicking injured central nervous system.

4. How hard is the CNS hardware?

Review 5. Failed central nervous system regeneration: a downside of immune privilege?

6. Chronic enhancement of the intrinsic growth capacity of sensory neurons combined with the degradation of inhibitory proteoglycans allows functional regeneration of sensory axons through the dorsal root entry zone in the mammalian spinal cord.

Review 7. Molecular targets in spinal cord injury.

8. Intrathecal treatment with anti-Nogo-A antibody improves functional recovery in adult rats after stroke.

9. Use of polysialic acid in repair of the central nervous system.

10. Differential effects of myocilin and optineurin, two glaucoma genes, on neurite outgrowth.