| Literature DB >> 15018924 |
Weiqin Jiang1, Vernon C Alford, Yuhong Qiu, Sheela Bhattacharjee, T Matthew John, Donna Haynes-Johnson, Patricia J Kraft, Scott G Lundeen, Zhihua Sui.
Abstract
The synthesis of the fused tetracyclic pyrroloquinolones 9a-i in four steps is described. The PDE5 inhibitory activities of these compounds, their selectivities against PDE1, PDE2, PDE3, PDE4 and PDE6, the preclinical pharmacokinetic assessments and the in vivo efficacy in increasing intracavernosal pressure are presented and discussed.Entities:
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Year: 2004 PMID： 15018924 DOI： 10.1016/j.bmc.2003.12.044
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641