Literature DB >> 15018551

Tissue molecular ion imaging by gold cluster ion bombardment.

David Touboul1, Fréderic Halgand, Alain Brunelle, Reinhard Kersting, Elke Tallarek, Birgit Hagenhoff, Olivier Laprévote.   

Abstract

The use of gold cluster focused ion beams produced by a liquid metal ion gun in a TOF-SIMS mass spectrometer is shown to dramatically enhance secondary ion emission of phospholipids and peptides. The method has been successfully tested with cells grown onto plastic slips and with mouse brain slices, without any treatment of the samples. Very reliable time-of-flight mass spectra are acquired with a low primary ion dose of a few 10(7) ions, and high lateral resolution molecular ion images are obtained for heavy ions of great biological interest. This approach offers new opportunities in pharmacological and biological research fields by localizing compounds of interest such as drugs or metabolites in tissues.

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Year:  2004        PMID： 15018551     DOI： 10.1021/ac035243z

Source DB:  PubMed          Journal:  Anal Chem        ISSN： 0003-2700            Impact factor:   6.986


  35 in total

Review 1.  Mass spectrometric imaging for biomedical tissue analysis.

Authors:  Kamila Chughtai; Ron M A Heeren
Journal:  Chem Rev       Date:  2010-05-12       Impact factor: 60.622

2.  Improvement of biological time-of-flight-secondary ion mass spectrometry imaging with a bismuth cluster ion source.

Authors:  David Touboul; Felix Kollmer; Ewald Niehuis; Alain Brunelle; Olivier Laprévote
Journal:  J Am Soc Mass Spectrom       Date:  2005-10       Impact factor: 3.109

3.  Fluorinated colloidal gold immunolabels for imaging select proteins in parallel with lipids using high-resolution secondary ion mass spectrometry.

Authors:  Robert L Wilson; Jessica F Frisz; William P Hanafin; Kevin J Carpenter; Ian D Hutcheon; Peter K Weber; Mary L Kraft
Journal:  Bioconjug Chem       Date:  2012-02-15       Impact factor: 4.774

4.  Direct comparison of Au(3)(+) and C(60)(+) cluster projectiles in SIMS molecular depth profiling.

Authors:  Juan Cheng; Joseph Kozole; Robert Hengstebeck; Nicholas Winograd
Journal:  J Am Soc Mass Spectrom       Date:  2006-11-21       Impact factor: 3.109

5.  Automated, feature-based image alignment for high-resolution imaging mass spectrometry of large biological samples.

Authors:  Alexander Broersen; Robert van Liere; A F Maarten Altelaar; Ron M A Heeren; Liam A McDonnell
Journal:  J Am Soc Mass Spectrom       Date:  2008-03-18       Impact factor: 3.109

Review 6.  Mass spectrometry imaging, an emerging technology in neuropsychopharmacology.

Authors:  Mohammadreza Shariatgorji; Per Svenningsson; Per E Andrén
Journal:  Neuropsychopharmacology       Date:  2013-08-21       Impact factor: 7.853

Review 7.  MALDI Imaging mass spectrometry: current frontiers and perspectives in pathology research and practice.

Authors:  Michaela Aichler; Axel Walch
Journal:  Lab Invest       Date:  2015-01-26       Impact factor: 5.662

8.  Time-of-flight secondary ion mass spectrometry imaging demonstrates the specific localization of deca-bromo-diphenyl-ether residues in the ovaries and adrenal glands of exposed rats.

Authors:  Alexandre Seyer; Anne Riu; Laurent Debrauwer; Nathalie Bourgès-Abella; Alain Brunelle; Olivier Laprévote; Daniel Zalko
Journal:  J Am Soc Mass Spectrom       Date:  2010-07-07       Impact factor: 3.109

9.  Simultaneous imaging of small metabolites and lipids in rat brain tissues at atmospheric pressure by laser ablation electrospray ionization mass spectrometry.

Authors:  Peter Nemes; Amina S Woods; Akos Vertes
Journal:  Anal Chem       Date:  2010-02-01       Impact factor: 6.986

10.  Metal imaging on surface of micro- and nanoelectronic devices by laser ablation inductively coupled plasma mass spectrometry and possibility to measure at nanometer range.

Authors:  Myroslav V Zoriy; Dirk Mayer; J Sabine Becker
Journal:  J Am Soc Mass Spectrom       Date:  2009-01-18       Impact factor: 3.109
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