Literature DB >> 1501711

A small metalloribozyme with a two-step mechanism.

T Pan1, O C Uhlenbeck.   

Abstract

An RNA molecule consisting of an asymmetric internal loop of six nucleotides can be rapidly and specifically cleaved by Pb2+ in the presence of Mg2+. The 5' cleavage product terminates with a 3' phosphomonoester generated from a 2',3'-cyclic phosphodiester reaction intermediate. This two-step reaction mechanism resembles that of many protein ribonucleases but has not previously been observed for reactions catalysed by RNA.

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Year:  1992        PMID： 1501711     DOI： 10.1038/358560a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  43 in total

1.  Structure of a regulatory 3' untranslated region from Trypanosoma brucei.

Authors:  M Drozdz; C Clayton
Journal:  RNA       Date:  1999-12       Impact factor: 4.942

2.  Intramolecular secondary structure rearrangement by the kissing interaction of the Neurospora VS ribozyme.

Authors:  A A Andersen; R A Collins
Journal:  Proc Natl Acad Sci U S A       Date:  2001-06-26       Impact factor: 11.205

3.  Kissing complex-mediated dimerisation of HIV-1 RNA: coupling extended duplex formation to ribozyme cleavage.

Authors:  Nikolai Windbichler; Michael Werner; Renée Schroeder
Journal:  Nucleic Acids Res       Date:  2003-11-15       Impact factor: 16.971

4.  Searching for a DNAzyme Version of the Leadzyme.

Authors:  Runjhun Saran; Qingyun Chen; Juewen Liu
Journal:  J Mol Evol       Date:  2015-10-12       Impact factor: 2.395

Review 5.  Two distinct catalytic strategies in the hepatitis δ virus ribozyme cleavage reaction.

Authors:  Barbara L Golden
Journal:  Biochemistry       Date:  2011-10-17       Impact factor: 3.162

Review 6.  Functional nucleic acid sensors.

Authors:  Juewen Liu; Zehui Cao; Yi Lu
Journal:  Chem Rev       Date:  2009-05       Impact factor: 60.622

7.  Conformationally restricted nucleotides as a probe of structure-function relationships in RNA.

Authors:  Kristine R Julien; Minako Sumita; Po-Han Chen; Ite A Laird-Offringa; Charles G Hoogstraten
Journal:  RNA       Date:  2008-07-02       Impact factor: 4.942

8.  Enrichment for RNA molecules that bind a Diels-Alder transition state analog.

Authors:  K N Morris; T M Tarasow; C M Julin; S L Simons; D Hilvert; L Gold
Journal:  Proc Natl Acad Sci U S A       Date:  1994-12-20       Impact factor: 11.205

9.  Square-shaped RNA particles from different RNA folds.

Authors:  Isil Severcan; Cody Geary; Erik Verzemnieks; Arkadiusz Chworos; Luc Jaeger
Journal:  Nano Lett       Date:  2009-03       Impact factor: 11.189

10.  Lead cleavage sites in the core structure of group I intron-RNA.

Authors:  B Streicher; U von Ahsen; R Schroeder
Journal:  Nucleic Acids Res       Date:  1993-01-25       Impact factor: 16.971
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