| Literature DB >> 15016556 |
Achim H-P Krauss1, David F Woodward.
Abstract
Bimatoprost is a pharmacologically unique and highly efficacious anti-glaucoma agent. It appears to mimic the activity of the prostamides, which are biosynthesized from the natural endocannabinoid anandamide by the enzyme cyclo-oxygenase 2 (COX-2). Bimatoprost has also been suggested to lower intraocular pressure by behaving as a prodrug or, alternatively, by stimulating FP receptors directly. These three distinctly different hypotheses for the mechanism of bimatoprost activity are discussed in the light of current evidence.Entities:
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Year: 2004 PMID： 15016556 DOI： 10.1016/j.survophthal.2003.12.014
Source DB: PubMed Journal: Surv Ophthalmol ISSN： 0039-6257 Impact factor: 6.048