| Literature DB >> 15016554 |
Sang Taek Oh1, Jung Seon Seo, Uk Yeol Moon, Kyeong Hee Kang, Dong-Jik Shin, Sungjoo Kim Yoon, Woo Ho Kim, Jae-Gahb Park, Suk Kyeong Lee.
Abstract
In a process seeking out a good model cell line for Epstein-Barr virus (EBV)-associated gastric cancer, we found that one previously established gastric adenocarcinoma cell line is infected with type 1 EBV. This SNU-719 cell line from a Korean patient expressed cytokeratin without CD19 or CD21 expression. In SNU-719, EBNA1 and LMP2A were expressed, while LMP1 and EBNA2 were not. None of the tested lytic EBV proteins were detected in this cell line unless stimulated with phorbol ester. EBV infection was also shown in the original carcinoma tissue of SNU-719 cell line. Our results support the possibility of a CD21-independent EBV infection of gastric epithelial cells in vivo. As the latent EBV gene expression pattern of SNU-719 closely resembles that of the EBV-associated gastric cancer, this naturally derived cell line may serve as a valuable model system to clarify the precise role of EBV in gastric carcinogenesis.Entities:
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Year: 2004 PMID： 15016554 DOI： 10.1016/j.virol.2003.12.005
Source DB: PubMed Journal: Virology ISSN： 0042-6822 Impact factor: 3.616