| Literature DB >> 15016369 |
Abstract
The analysis of correlated sequence variation in evolutionarily related proteins is beginning to provide useful information regarding allosteric coupling between different functional sites. Such an analysis has been carried out for the nuclear hormone receptors, and the conclusions tested by making mutations that switch the allosteric response to ligands of RXR heterodimers.Entities:
Mesh:
Substances:
Year: 2004 PMID: 15016369 DOI: 10.1016/s0092-8674(04)00125-4
Source DB: PubMed Journal: Cell ISSN: 0092-8674 Impact factor: 41.582