Literature DB >> 15015628

Observation on in situ hybridization and immunocytochemistry of matrix metalloproteinases in rat pancreas.

Lihua Tang1, Shenghong Liu, Fang Wang, Zilong Liu, Yun Xu, Xiaoli Wang, Zhaochun Li.   

Abstract

In situ hybridization and immunocytochemical techniques were employed to examine the expression of matrix metalloproteinases-1 (MMP-1) and to identify the pattern of its distribution in rat pancreas. The results indicated that the signal of MMP-1 mRNA and MMP-1 positive immunoreaction were detected in some fiberoblasts around interlobular ducts and exocrine cell in margin acinus of some lobules, but the signal of MMP-1 mRNA and MMP-1 positive immunoreaction could not be detected in most of other acinus and islets of pancreas. It is concluded that the expression of MMP-1 in above cells of rat might play an important role in acinar proliferation and differentiation of rat pancreatic tissues.

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Year:  2003        PMID: 15015628     DOI: 10.1007/BF02829410

Source DB:  PubMed          Journal:  J Huazhong Univ Sci Technolog Med Sci        ISSN: 1672-0733


  8 in total

1.  cDNA sequence and mRNA tissue distribution of a novel human matrix metalloproteinase with a potential transmembrane segment.

Authors:  H Will; B Hinzmann
Journal:  Eur J Biochem       Date:  1995-08-01

2.  Expression of the MMP-1 in human pancreatic carcinoma: relationship with prognostic factor.

Authors:  T Ito; M Ito; J Shiozawa; S Naito; T Kanematsu; I Sekine
Journal:  Mod Pathol       Date:  1999-07       Impact factor: 7.842

3.  Decreased type IV collagenase activity in experimental pancreatic fibrosis.

Authors:  E K Ng; B L Barent; G S Smith; R J Joehl; K M Murayama
Journal:  J Surg Res       Date:  2001-03       Impact factor: 2.192

4.  The influence of transforming growth factor beta 1 on the expression of genes coding for matrix metalloproteinases and tissue inhibitors of metalloproteinases during regeneration from cerulein-induced pancreatitis.

Authors:  F Müller-Pillasch; T M Gress; H Yamaguchi; M Geng; G Adler; A Menke
Journal:  Pancreas       Date:  1997-08       Impact factor: 3.327

5.  Expression of membrane-type matrix metalloproteinase-1 in human pancreatic adenocarcinomas.

Authors:  T Imamura; G Ohshio; M Mise; T Harada; H Suwa; N Okada; Z Wang; S Yoshitomi; T Tanaka; H Sato; S Arii; M Seiki; M Imamura
Journal:  J Cancer Res Clin Oncol       Date:  1998       Impact factor: 4.553

6.  Balance of expression of genes coding for extracellular matrix proteins and extracellular matrix degrading proteases in chronic pancreatitis.

Authors:  T M Gress; F Müller-Pillasch; M M Lerch; H Friess; M Büchler; H G Beger; G Adler
Journal:  Z Gastroenterol       Date:  1994-04       Impact factor: 2.000

7.  Impaired migration and delayed differentiation of pancreatic islet cells in mice lacking EGF-receptors.

Authors:  P J Miettinen; M Huotari; T Koivisto; J Ustinov; J Palgi; S Rasilainen; E Lehtonen; J Keski-Oja; T Otonkoski
Journal:  Development       Date:  2000-06       Impact factor: 6.868

8.  TGF-beta plays a key role in morphogenesis of the pancreatic islets of Langerhans by controlling the activity of the matrix metalloproteinase MMP-2.

Authors:  F Miralles; T Battelino; P Czernichow; R Scharfmann
Journal:  J Cell Biol       Date:  1998-11-02       Impact factor: 10.539

  8 in total

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