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Literature DB >> 15015496

Viral DNA polymerase scanning and the gymnastics of Sendai virus RNA synthesis.

Daniel Kolakofsky¹, Philippe Le Mercier, Frédéric Iseni, Dominique Garcin.

Abstract

mRNA synthesis from nonsegmented negative-strand RNA virus (NNV) genomes is unique in tht the genome RNA is embedded in an N protein assembly (the nucleocapsid) and the viral RNA polymerase does not dissociate from the template after release of each mRNA, but rather scans the genome RNA for the next gene-start site. A revised model for NNV RNA synthesis is presented, in which RNA polymerase scanning plays a prominent role. Polymerase scanning of the template is known to occur as the viral transcriptase negotiates gene junctions without falling off the template.

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Year: 2004 PMID： 15015496 DOI： 10.1016/j.virol.2003.10.031

Source DB: PubMed Journal: Virology ISSN： 0042-6822 Impact factor: 3.616

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Cited

55 in total

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2. Identification of internal sequences in the 3' leader region of human respiratory syncytial virus that enhance transcription and confer replication processivity.

Authors: David R McGivern; Peter L Collins; Rachel Fearns
Journal: J Virol Date: 2005-02 Impact factor: 5.103

3. Dynamics of viral RNA synthesis during measles virus infection.

Authors: Sébastien Plumet; W Paul Duprex; Denis Gerlier
Journal: J Virol Date: 2005-06 Impact factor: 5.103

4. Evidence that the respiratory syncytial virus polymerase is recruited to nucleotides 1 to 11 at the 3' end of the nucleocapsid and can scan to access internal signals.

Authors: Vanessa M Cowton; Rachel Fearns
Journal: J Virol Date: 2005-09 Impact factor: 5.103

Viral DNA polymerase scanning and the gymnastics of Sendai virus RNA synthesis.

1. Oligomerization of Mumps Virus Phosphoprotein.

2. Identification of internal sequences in the 3' leader region of human respiratory syncytial virus that enhance transcription and confer replication processivity.

3. Dynamics of viral RNA synthesis during measles virus infection.

4. Evidence that the respiratory syncytial virus polymerase is recruited to nucleotides 1 to 11 at the 3' end of the nucleocapsid and can scan to access internal signals.

5. Intrinsic dynamics of the partly unstructured PX domain from the Sendai virus RNA polymerase cofactor P.

6. Protein domain definition should allow for conditional disorder.

7. Evidence that the polymerase of respiratory syncytial virus initiates RNA replication in a nontemplated fashion.

8. Host CARD11 Inhibits Newcastle Disease Virus Replication by Suppressing Viral Polymerase Activity in Neurons.

Review 9. Interplay between innate immunity and negative-strand RNA viruses: towards a rational model.

10. Structure of a paramyxovirus polymerase complex reveals a unique methyltransferase-CTD conformation.