Literature DB >> 15014637

Methylphenidate Abuse and Psychiatric Side Effects.

W Alexander Morton1, Gwendolyn G. Stockton.   

Abstract

Methylphenidate is a central nervous system stimulant drug that has become the primary drug of choice in treating attention-deficit/hyperactivity disorder in children. Side effects are usually mild and are generally well tolerated by patients. Along with increases in prescribing frequency, the potential for abuse has increased. Intranasal abuse produces effects rapidly that are similar to the effects of cocaine in both onset and type. The clinical picture of stimulant abuse produces a wide array of psychiatric symptoms. There is little in the literature to differentiate methylphenidate from other stimulants when they are abused. The need for education of all involved with the use of methylphenidate is discussed to help prevent an increasing pattern of methylphenidate abuse.

Entities:  

Year:  2000        PMID: 15014637      PMCID: PMC181133          DOI: 10.4088/pcc.v02n0502

Source DB:  PubMed          Journal:  Prim Care Companion J Clin Psychiatry        ISSN: 1523-5998


  53 in total

1.  Reinforcing effects of psychostimulants in humans are associated with increases in brain dopamine and occupancy of D(2) receptors.

Authors:  N D Volkow; G J Wang; J S Fowler; J Logan; S J Gatley; C Wong; R Hitzemann; N R Pappas
Journal:  J Pharmacol Exp Ther       Date:  1999-10       Impact factor: 4.030

Review 2.  Treatment of attention-deficit-hyperactivity disorder.

Authors:  J Elia; P J Ambrosini; J L Rapoport
Journal:  N Engl J Med       Date:  1999-03-11       Impact factor: 91.245

3.  Is ritalin an addiction-producing drug?

Authors:  B RIOUX
Journal:  Dis Nerv Syst       Date:  1960-06

Review 4.  Some relationships between addiction and drug delivery to the brain.

Authors:  W H Oldendorf
Journal:  NIDA Res Monogr       Date:  1992

Review 5.  Methylphenidate: its pharmacology and uses.

Authors:  T D Challman; J J Lipsky
Journal:  Mayo Clin Proc       Date:  2000-07       Impact factor: 7.616

6.  Detection of the novel metabolite ethylphenidate after methylphenidate overdose with alcohol coingestion.

Authors:  J S Markowitz; B K Logan; F Diamond; K S Patrick
Journal:  J Clin Psychopharmacol       Date:  1999-08       Impact factor: 3.153

7.  Dopamine-transporter occupancy after intravenous doses of cocaine and methylphenidate in mice and humans.

Authors:  S J Gatley; N D Volkow; A N Gifford; J S Fowler; S L Dewey; Y S Ding; J Logan
Journal:  Psychopharmacology (Berl)       Date:  1999-09-01       Impact factor: 4.530

8.  Trends in the prescribing of psychotropic medications to preschoolers.

Authors:  J M Zito; D J Safer; S dosReis; J F Gardner; M Boles; F Lynch
Journal:  JAMA       Date:  2000-02-23       Impact factor: 56.272

Review 9.  Diagnosis and treatment of attention deficit hyperactivity disorder (ADHD).

Authors: 
Journal:  NIH Consens Statement       Date:  1998 Nov 16-18

10.  Prevalence of cocaine use among residents of New York City who committed suicide during a one-year period.

Authors:  P M Marzuk; K Tardiff; A C Leon; M Stajic; E B Morgan; J J Mann
Journal:  Am J Psychiatry       Date:  1992-03       Impact factor: 18.112

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  38 in total

1.  Locus coeruleus neuronal activity correlates with behavioral response to acute and chronic doses of methylphenidate (Ritalin) in adolescent rats.

Authors:  Natasha Kharas; Cruz Reyes-Vazquez; Nachum Dafny
Journal:  J Neural Transm (Vienna)       Date:  2017-07-20       Impact factor: 3.575

2.  Detection of signals of abuse and dependence applying disproportionality analysis.

Authors:  V Pauly; M Lapeyre-Mestre; D Braunstein; M Rueter; X Thirion; E Jouanjus; J Micallef
Journal:  Eur J Clin Pharmacol       Date:  2014-11-20       Impact factor: 2.953

Review 3.  Misuse of stimulant medication among college students: a comprehensive review and meta-analysis.

Authors:  Kari Benson; Kate Flory; Kathryn L Humphreys; Steve S Lee
Journal:  Clin Child Fam Psychol Rev       Date:  2015-03

4.  Repeated administration of methylphenidate in young, adolescent, and mature rats affects the response to cocaine later in adulthood.

Authors:  Annelyn Torres-Reverón; Diana L Dow-Edwards
Journal:  Psychopharmacology (Berl)       Date:  2005-10-15       Impact factor: 4.530

5.  The effects of adolescent methylphenidate self-administration on responding for a conditioned reward, amphetamine-induced locomotor activity, and neuronal activation.

Authors:  Christie L Burton; José N Nobrega; Paul J Fletcher
Journal:  Psychopharmacology (Berl)       Date:  2009-12-18       Impact factor: 4.530

6.  Methylphenidate and cocaine self-administration produce distinct dopamine terminal alterations.

Authors:  Erin S Calipari; Mark J Ferris; James R Melchior; Kristel Bermejo; Ali Salahpour; David C S Roberts; Sara R Jones
Journal:  Addict Biol       Date:  2012-03-28       Impact factor: 4.280

7.  Subjective Report of Side Effects of Prescribed and Nonprescribed Psychostimulant Use in Young Adults.

Authors:  Tess E Smith; Michelle M Martel; Alan D DeSantis
Journal:  Subst Use Misuse       Date:  2016-11-21       Impact factor: 2.164

8.  Weekday-only chronic oral methylphenidate self-administration in male rats: Reversibility of the behavioral and physiological effects.

Authors:  Emily Carias; Dennis Fricke; Abisha Vijayashanthar; Lauren Smith; Rathini Somanesan; Connor Martin; Leanna Kalinowski; Daniel Popoola; Michael Hadjiargyrou; David E Komatsu; Panayotis K Thanos
Journal:  Behav Brain Res       Date:  2018-08-24       Impact factor: 3.332

9.  Differential effects of methylphenidate and cocaine on GABA transmission in sensory thalamic nuclei.

Authors:  Belén Goitia; Mariana Raineri; Laura E González; José L Rozas; Edgar Garcia-Rill; Verónica Bisagno; Francisco J Urbano
Journal:  J Neurochem       Date:  2013-01-07       Impact factor: 5.372

10.  ADHD & Pharmacotherapy: Past, Present and Future: A Review of the Changing Landscape of Drug Therapy for Attention Deficit Hyperactivity Disorder.

Authors:  J J Connolly; J T Glessner; J Elia; H Hakonarson
Journal:  Ther Innov Regul Sci       Date:  2015-09       Impact factor: 1.778

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