David J Browning1. 1. Charlotte Eye, Ear, Nose, and Throat Associates, Charlotte, North Carolina 28210, USA. djbrowining@carolina.rr.com
Abstract
PURPOSE: To report a side effect of quinacrine therapy for malaria. DESIGN: Case report. METHODS: Review of clinical chart and photographs. SETTING: Private retina practice. RESULTS: A patient developed a bilaterally symmetric bull's-eye maculopathy 45 years after taking quinacrine for 18 months as prophylaxis against malaria. Progression of the clinical picture was documented over 15 years of follow-up. The clinical picture was identical to that of chloroquine and hydroxychloroquine maculopathy. CONCLUSIONS: Low dosages of quinacrine used for malaria prophylaxis can be associated with a delayed, severe maculopathy indistinguishable from chloroquine maculopathy in certain patients.
PURPOSE: To report a side effect of quinacrine therapy for malaria. DESIGN: Case report. METHODS: Review of clinical chart and photographs. SETTING: Private retina practice. RESULTS: A patient developed a bilaterally symmetric bull's-eye maculopathy 45 years after taking quinacrine for 18 months as prophylaxis against malaria. Progression of the clinical picture was documented over 15 years of follow-up. The clinical picture was identical to that of chloroquine and hydroxychloroquinemaculopathy. CONCLUSIONS: Low dosages of quinacrine used for malaria prophylaxis can be associated with a delayed, severe maculopathy indistinguishable from chloroquinemaculopathy in certain patients.
Authors: Claudia Worth; Imran H Yusuf; Bethany Turner; Hanae Gourier; Emma E Brooks; Daniel O Mort; Srilakshmi Sharma; Susan M Downes; Raashid A Luqmani Journal: Rheumatol Adv Pract Date: 2018-05-08