BACKGROUND: Neuroimaging reports of increases in signal hyperintensities in white and deep gray matter and other work indicate that there might be an inflammatory response in affective disorders. METHODS: The microvascular immunoreactivity of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 was measured with image analysis in postmortem tissue from the anterior cingulate cortex (ACC) and dorsolateral prefrontal cortex (DLPFC) from 15 unipolar and 15 bipolar subjects and compared with each other and with 15 subjects with schizophrenia and 15 control subjects. RESULTS: Intercellular adhesion molecule-1 immunoreactivity in gray and white matter of the ACC in bipolar subjects was increased compared with control subjects (gray: p =.001; white: p <.001) and schizophrenic subjects (gray: p =.016; white: p =.025) and modestly increased in white matter compared with unipolar subjects (p =.049). No such differences were found in the DLPFC. CONCLUSIONS: These findings are consistent with the presence of an inflammatory response in the ACC in bipolar disorder.
BACKGROUND: Neuroimaging reports of increases in signal hyperintensities in white and deep gray matter and other work indicate that there might be an inflammatory response in affective disorders. METHODS: The microvascular immunoreactivity of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 was measured with image analysis in postmortem tissue from the anterior cingulate cortex (ACC) and dorsolateral prefrontal cortex (DLPFC) from 15 unipolar and 15 bipolar subjects and compared with each other and with 15 subjects with schizophrenia and 15 control subjects. RESULTS:Intercellular adhesion molecule-1 immunoreactivity in gray and white matter of the ACC in bipolar subjects was increased compared with control subjects (gray: p =.001; white: p <.001) and schizophrenic subjects (gray: p =.016; white: p =.025) and modestly increased in white matter compared with unipolar subjects (p =.049). No such differences were found in the DLPFC. CONCLUSIONS: These findings are consistent with the presence of an inflammatory response in the ACC in bipolar disorder.
Authors: Tanya T Nguyen; Sheena I Dev; Guanqing Chen; Sharon C Liou; Averria Sirkin Martin; Michael R Irwin; Judith E Carroll; Xin Tu; Dilip V Jeste; Lisa T Eyler Journal: Eur Arch Psychiatry Clin Neurosci Date: 2017-09-23 Impact factor: 5.270
Authors: Jose Javier Miguel-Hidalgo; James C Overholser; George J Jurjus; Herbert Y Meltzer; Lesa Dieter; Lisa Konick; Craig A Stockmeier; Grazyna Rajkowska Journal: J Affect Disord Date: 2011-05-04 Impact factor: 4.839
Authors: Auriel A Willette; Catherine Gallagher; Barbara B Bendlin; Donald G McLaren; Erik K Kastman; Elisa Canu; Kris J Kosmatka; Aaron S Field; Andrew L Alexander; Ricki J Colman; Mary-Lou L Voytko; Richard H Weindruch; Christopher L Coe; Sterling C Johnson Journal: Neurobiol Aging Date: 2010-08-05 Impact factor: 4.673
Authors: William T Regenold; K Calvin Hisley; Pornima Phatak; Christopher M Marano; Abraham Obuchowski; David M Lefkowitz; Amritpal Sassan; Sameer Ohri; Tony L Phillips; Narveen Dosanjh; Robert R Conley; Rao Gullapalli Journal: Bipolar Disord Date: 2008-11 Impact factor: 6.744
Authors: Marcus V Zanetti; Marcel P Jackowski; Amelia Versace; Jorge R C Almeida; Stefanie Hassel; Fábio L S Duran; Geraldo F Busatto; David J Kupfer; Mary L Phillips Journal: Eur Arch Psychiatry Clin Neurosci Date: 2009-03-03 Impact factor: 5.270