| Literature DB >> 15013785 |
Alfred Cortés1, Mata Mellombo, Ariadna Benet, Kerry Lorry, Lawrence Rare, John C Reeder.
Abstract
The merozoite surface protein 2 (MSP2) is a leading asexual-stage malaria vaccine candidate that has already proven to have an effect in phase I/IIb vaccine trials, where it was tested in combination with other antigens. Alleles of msp2 fall within two major allelic families, 3D7 and FC27. We analyzed the msp2 genotype in 306 asymptomatic and 63 symptomatic infections from the Wosera region of Papua New Guinea. The multiplicity of infection and the distribution of msp2 alleles was similar to that found in previous studies in the region, but there was no association found between FC27-type or 3D7-type forms of MSP2 and clinical malaria.Entities:
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Year: 2004 PMID： 15013785 DOI： 10.1016/j.exppara.2004.01.010
Source DB: PubMed Journal: Exp Parasitol ISSN： 0014-4894 Impact factor: 2.011