| Literature DB >> 15013623 |
Jie Pan1, Louis-Bruno Ruest, Suying Xu, Eugenia Wang.
Abstract
During early postnatal development, a switch occurs between eEF1A-1/EF-1alpha and eEF1A-2/S1, homologous peptide elongation factors, in brain, heart, and skeletal muscle; eEF1A-2/S1 becomes the major form expressed in maturity. By immunofluorescent labeling, we detected both homologues in the developing brains of wild-type and wasted mutant mice, carrying a deletion in the eEF1A-2/S1 gene; we found that brain expression of eEF1A-2/S1 protein is restricted to mature, terminally differentiated neurons, and coincides with the disappearance of eEF1A-1/EF-1alpha 20 days after birth. Furthermore, no elongation factor 1A is present in wasted mutant mice neurons following the developmental switch, indicating that the genetic regulation silencing eEF1A-1/EF-1alpha is still functional.Entities:
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Year: 2004 PMID： 15013623 PMCID： PMC2830753 DOI： 10.1016/j.devbrainres.2003.10.011
Source DB: PubMed Journal: Brain Res Dev Brain Res ISSN： 0165-3806