Literature DB >> 15013481

Quantitative measurement of histamine H(1) receptors in human brains by PET and [11C]doxepin.

Hideki Mochizuki1, Yuichi Kimura, Kenji Ishii, Keiichi Oda, Toru Sasaki, Manabu Tashiro, Kazuhiko Yanai, Kiichi Ishiwata.   

Abstract

The aim of this study is to establish a method for quantitative measurement of histamine H(1) receptor (H1R) in human brain by PET and [(11)C]doxepin ([(11)C]DOX). The estimated parameters with a two-compartment model were stable for the initial values for parameter estimation but those with a three-compartment model were not. This finding suggests that the H1R measured by the [(11)C]DOX and PET can be evaluated with a two-compartment model.

Entities:  

Mesh：

Substances：

Year:  2004        PMID： 15013481     DOI： 10.1016/j.nucmedbio.2003.08.010

Source DB:  PubMed          Journal:  Nucl Med Biol        ISSN： 0969-8051            Impact factor:   2.408


  5 in total

1.  Brain histamine H receptor occupancy of orally administered antihistamines measured by positron emission tomography with (11)C-doxepin in a placebo-controlled crossover study design in healthy subjects: a comparison of olopatadine and ketotifen.

Authors:  Manabu Tashiro; Hideki Mochizuki; Yumiko Sakurada; Kenji Ishii; Keiichi Oda; Yuichi Kimura; Toru Sasaki; Kiichi Ishiwata; Kazuhiko Yanai
Journal:  Br J Clin Pharmacol       Date:  2006-01       Impact factor: 4.335

Review 2.  Modeling of PET data in CNS drug discovery and development.

Authors:  Katarina Varnäs; Andrea Varrone; Lars Farde
Journal:  J Pharmacokinet Pharmacodyn       Date:  2013-05-10       Impact factor: 2.745

3.  Effects of sedative and nonsedative antihistamines on prefrontal activity during verbal fluency task in young children: a near-infrared spectroscopy (NIRS) study.

Authors:  Takeo Tsujii; Sayako Masuda; Eriko Yamamoto; Takayuki Ohira; Takekazu Akiyama; Takao Takahashi; Shigeru Watanabe
Journal:  Psychopharmacology (Berl)       Date:  2009-08-25       Impact factor: 4.530

4.  Histamine H₁ receptor occupancy by the new-generation antidepressants fluvoxamine and mirtazapine: a positron emission tomography study in healthy volunteers.

Authors:  Hirotoshi Sato; Chihiro Ito; Manabu Tashiro; Kotaro Hiraoka; Katsuhiko Shibuya; Yoshihito Funaki; Ren Iwata; Hiroo Matsuoka; Kazuhiko Yanai
Journal:  Psychopharmacology (Berl)       Date:  2013-06-01       Impact factor: 4.530

5.  Brain histamine H1 receptor occupancy after oral administration of desloratadine and loratadine.

Authors:  Tadaho Nakamura; Kotaro Hiraoka; Ryuichi Harada; Takuro Matsuzawa; Yoichi Ishikawa; Yoshihito Funaki; Takeo Yoshikawa; Manabu Tashiro; Kazuhiko Yanai; Nobuyuki Okamura
Journal:  Pharmacol Res Perspect       Date:  2019-07-12
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.