F Brambilla1, P Monteleone, M Maj. 1. Clinica Psichiatrica dell'Università, SUN, Naples, Italy. francesca.brambilla4@tin.it
Abstract
BACKGROUND: Immune function is altered in adult depressed patients. The aim of our study was to see whether or not cytokine secretion is impaired at a very young phase of development of depressive disorders, possibly being pathogenetically involved in their course. METHODS: Basal plasma concentrations of interleukin-1beta (Il-1beta) and tumor necrosis factor-alpha (TNF-alpha) were measured radioimmunologically in 22 drug-free children-adolescents, 11 with recurrent major depressive disorders (MDD) and 11 with dysthymia (DYS), and in 11 psychophysically healthy age-sex matched controls. Depression was monitored using the Poznanski Rating Scale and Anxiety with the Reynold Rating Scale. RESULTS: Il-1beta levels were not significantly different in MDD from controls and significantly higher than normal in DYS subjects. TNF-alpha levels were not significantly different in MDD patients from controls and significantly lower than normal in DYS patients. Cytokine concentrations were correlated with anxious and depressive symptomatology in MDD but not in DYS patients. CONCLUSIONS: There is a cytokine pathology in depressive disorders of obscure etiopathogenetical significance.
BACKGROUND: Immune function is altered in adult depressedpatients. The aim of our study was to see whether or not cytokine secretion is impaired at a very young phase of development of depressive disorders, possibly being pathogenetically involved in their course. METHODS: Basal plasma concentrations of interleukin-1beta (Il-1beta) and tumor necrosis factor-alpha (TNF-alpha) were measured radioimmunologically in 22 drug-free children-adolescents, 11 with recurrent major depressive disorders (MDD) and 11 with dysthymia (DYS), and in 11 psychophysically healthy age-sex matched controls. Depression was monitored using the Poznanski Rating Scale and Anxiety with the Reynold Rating Scale. RESULTS:Il-1beta levels were not significantly different in MDD from controls and significantly higher than normal in DYS subjects. TNF-alpha levels were not significantly different in MDDpatients from controls and significantly lower than normal in DYS patients. Cytokine concentrations were correlated with anxious and depressive symptomatology in MDD but not in DYS patients. CONCLUSIONS: There is a cytokine pathology in depressive disorders of obscure etiopathogenetical significance.
Authors: Vilma Gabbay; Rachel G Klein; Carmen M Alonso; James S Babb; Melissa Nishawala; Georgette De Jesus; Glenn S Hirsch; Pauline M Z Hottinger-Blanc; Charles J Gonzalez Journal: J Affect Disord Date: 2008-09-13 Impact factor: 4.839
Authors: David J Miklowitz; Larissa C Portnoff; Casey C Armstrong; Danielle Keenan-Miller; Elizabeth C Breen; Keely A Muscatell; Naomi I Eisenberger; Michael R Irwin Journal: Psychiatry Res Date: 2016-05-07 Impact factor: 3.222