| Literature DB >> 15013059 |
Mohammad Sayyah1, Iraj Toubeihaye Najafabadi, Siamak Beheshti, Sayeh Majzoob.
Abstract
Seizures are common sequel to brain insults in cases such as stroke, trauma and infection where there is a certain neuroinflammation. Intracerebroventricular (i.c.v.) administration of lipopolysaccharide (LPS) induces an inflammatory state in brain that is used as a model of neuroinflammation. We studied the effect of LPS (0.25 and 2.5 microg/rat, i.c.v.) on development of electrical kindling of the amygdala and on fully-kindled seizures. LPS, at the doses used, had no effect on fully-kindled seizures and afterdischarge (AD) duration at 0.5, 2 or 4h after administration. However, daily injection of LPS (2.5 microg/rat) retarded acquisition of kindled behavioral seizures. This antiepileptogenic effect could be due to the release of inflammatory mediators from microglia and the related morphological and functional changes in synaptic neurotransmission.Entities:
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Year: 2003 PMID： 15013059 DOI： 10.1016/j.eplepsyres.2003.11.002
Source DB: PubMed Journal: Epilepsy Res ISSN： 0920-1211 Impact factor: 3.045