| Literature DB >> 15013015 |
James R Epperson1, Jeffrey A Deskus, Anthony J Gentile, Lawrence G Iben, Elaine Ryan, Nathan S Sarbin.
Abstract
A series of 4-substituted anilides with human melatonergic affinity is reported. Butyramides 26, 39, 42, 52, 57, and 58 all demonstrated subnanomolar MT(2) binding affinity and MT(2) selectivity of at least 70-fold over the MT(1) receptor. Compound 26 demonstrated full agonism at the MT(2) receptor.Entities:
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Year: 2004 PMID： 15013015 DOI： 10.1016/j.bmcl.2003.11.030
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823