| Literature DB >> 15013008 |
Yao-Zhong Xu1, Xiaohui Zhang, Hai-Chen Wu, Andrew Massey, Peter Karran.
Abstract
4-Thio-5-bromo-2'-deoxyuridine (3a) is prepared from 5-bromo-2'-deoxyuridine (BrdU) and its key properties are explored. The thionucleoside (3a) can react readily with monobromobimane and produces high fluorescence. 3a has UV maximum absorption at 340 nm and can be incorporated into cellular DNA. The cells containing 3a become sensitive to UVA light, offering therapeutic potential for UVA-induced cell killing.Entities:
Mesh：
Substances：
Year: 2004 PMID： 15013008 DOI： 10.1016/j.bmcl.2003.11.069
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823