Literature DB >> 15013000

Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles.

Edgar R Wood1, Lee Kuyper, Kimberly G Petrov, Robert N Hunter, Philip A Harris, Karen Lackey.   

Abstract

The discovery, synthesis, potential binding mode, and in vitro kinase profile of 3-(3-bromo-4-hydroxy-5-(2'-methoxyphenyl)-benzylidene)-5-bromo-1,3-dihydro-pyrrolo[2,3-b]pyridin-2-one, 3-[(1-methyl-1H-indol-3-yl)methylene]-1,3-dihydro-2H-pyrrolo[3,2-b]-pyridin-2-one as potent TrkA inhibitors are discussed.

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Year:  2004        PMID： 15013000     DOI： 10.1016/j.bmcl.2003.12.002

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  33 in total

Review 1.  Perineural invasion and associated pain in pancreatic cancer.

Authors:  Aditi A Bapat; Galen Hostetter; Daniel D Von Hoff; Haiyong Han
Journal:  Nat Rev Cancer       Date:  2011-09-23       Impact factor: 60.716

2.  Nerve growth factor (NGF) regulates activity of nuclear factor of activated T-cells (NFAT) in neurons via the phosphatidylinositol 3-kinase (PI3K)-Akt-glycogen synthase kinase 3β (GSK3β) pathway.

Authors:  Man-Su Kim; Leonid P Shutov; Aswini Gnanasekaran; Zhihong Lin; Jacob E Rysted; Jason D Ulrich; Yuriy M Usachev
Journal:  J Biol Chem       Date:  2014-09-17       Impact factor: 5.157

3.  Theraputic targeting of Trk supresses tumor proliferation and enhances cisplatin activity in HNSCC.

Authors:  Turker Yilmaz; Tilahun Jiffar; Gabriel de la Garza; Heather Lin; Zvonimir Milas; Yoko Takahashi; Ehab Hanna; Terry MacIntyre; Jeffrey L Brown; Jeffrey N Myers; Michael E Kupferman
Journal:  Cancer Biol Ther       Date:  2010-09-23       Impact factor: 4.742

4.  Cellular assays for high-throughput screening for modulators of Trk receptor tyrosine kinases.

Authors:  Jun Wang; Michael K Hancock; Jeanne M Dudek; Kun Bi
Journal:  Curr Chem Genomics       Date:  2008-02-25

5.  Posttranslational protein knockdown coupled to receptor tyrosine kinase activation with phosphoPROTACs.

Authors:  John Hines; Jonathan D Gough; Timothy W Corson; Craig M Crews
Journal:  Proc Natl Acad Sci U S A       Date:  2013-05-14       Impact factor: 11.205

6.  DHEA inhibits acute microglia-mediated inflammation through activation of the TrkA-Akt1/2-CREB-Jmjd3 pathway.

Authors:  V I Alexaki; G Fodelianaki; A Neuwirth; C Mund; A Kourgiantaki; E Ieronimaki; K Lyroni; M Troullinaki; C Fujii; W Kanczkowski; A Ziogas; M Peitzsch; S Grossklaus; B Sönnichsen; A Gravanis; S R Bornstein; I Charalampopoulos; C Tsatsanis; T Chavakis
Journal:  Mol Psychiatry       Date:  2017-09-12       Impact factor: 15.992

7.  Paradoxical effect of TrkA inhibition in Alzheimer's disease models.

Authors:  Qiang Zhang; Olivier Descamps; Matthew J Hart; Karen S Poksay; Patricia Spilman; Darci J Kane; Olivia Gorostiza; Varghese John; Dale E Bredesen
Journal:  J Alzheimers Dis       Date:  2014       Impact factor: 4.472

8.  Tyrosine kinase nerve growth factor receptor switches from prosurvival to proapoptotic activity via Abeta-mediated phosphorylation.

Authors:  C Matrone; R Marolda; S Ciafrè; M T Ciotti; D Mercanti; P Calissano
Journal:  Proc Natl Acad Sci U S A       Date:  2009-06-19       Impact factor: 11.205

9.  A Twist-Snail axis critical for TrkB-induced epithelial-mesenchymal transition-like transformation, anoikis resistance, and metastasis.

Authors:  Marjon A Smit; Thomas R Geiger; Ji-Ying Song; Inna Gitelman; Daniel S Peeper
Journal:  Mol Cell Biol       Date:  2009-05-04       Impact factor: 4.272

10.  Fucoganglioside alpha-fucosyl(alpha-galactosyl)-GM1: a novel member of lipid membrane microdomain components involved in PC12 cell neuritogenesis.

Authors:  Yasuhiro Yamazaki; Yasuhiro Horibata; Yasuko Nagatsuka; Yoshio Hirabayashi; Tsutomu Hashikawa
Journal:  Biochem J       Date:  2007-10-01       Impact factor: 3.857
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