Literature DB >> 15012992

Design and synthesis of 3,7-diarylimidazopyridines as inhibitors of the VEGF-receptor KDR.

Zhicai Wu1, Mark E Fraley, Mark T Bilodeau, Mildred L Kaufman, Edward S Tasber, Adrienne E Balitza, George D Hartman, Kathleen E Coll, Keith Rickert, Jennifer Shipman, Bin Shi, Laura Sepp-Lorenzino, Kenneth A Thomas.   

Abstract

3,7-Diarylsubstituted imidazopyridines were designed and developed as a new class of KDR kinase inhibitors. A variety of imidazopyridines were synthesized and potent inhibitors of KDR kinase activity were identified with good aqueous solubility.

Entities:  

Mesh：

Substances：

Year:  2004        PMID： 15012992     DOI： 10.1016/j.bmcl.2003.12.007

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

1.  Identification of two novel RET kinase inhibitors through MCR-based drug discovery: design, synthesis and evaluation.

Authors:  Brendan Frett; Marialuisa Moccia; Francesca Carlomagno; Massimo Santoro; Hong-yu Li
Journal:  Eur J Med Chem       Date:  2014-09-08       Impact factor: 6.514

2.  Alpharetroviral self-inactivating vectors: long-term transgene expression in murine hematopoietic cells and low genotoxicity.

Authors:  Julia D Suerth; Tobias Maetzig; Martijn H Brugman; Niels Heinz; Jens-Uwe Appelt; Kerstin B Kaufmann; Manfred Schmidt; Manuel Grez; Ute Modlich; Christopher Baum; Axel Schambach
Journal:  Mol Ther       Date:  2012-02-14       Impact factor: 11.454

3.  Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors.

Authors:  Gregory D Cuny; Paul B Yu; Joydev K Laha; Xuechao Xing; Ji-Feng Liu; Carol S Lai; Donna Y Deng; Chetana Sachidanandan; Kenneth D Bloch; Randall T Peterson
Journal:  Bioorg Med Chem Lett       Date:  2008-06-27       Impact factor: 2.823

Review 4.  Applications of small molecule BMP inhibitors in physiology and disease.

Authors:  Charles C Hong; Paul B Yu
Journal:  Cytokine Growth Factor Rev       Date:  2009-11-14       Impact factor: 7.638

5.  Ab-initio and Conformational Analysis of a Potent VEGFR-2 Inhibitor: A Case Study on Motesanib.

Authors:  Ahmad Ebadi; Nima Razzaghi-Asl; Sara Shahabipour; Ramin Miri
Journal:  Iran J Pharm Res       Date:  2014       Impact factor: 1.696

6.  SH003 represses tumor angiogenesis by blocking VEGF binding to VEGFR2.

Authors:  Hyeong Sim Choi; Min Kyoung Kim; Kangwook Lee; Kang Min Lee; Youn Kyung Choi; Yong Cheol Shin; Sung-Gook Cho; Seong-Gyu Ko
Journal:  Oncotarget       Date:  2016-05-31

7.  Synthesis and biological evaluation of pyrazolo[1,5-a]-pyrimidine-containing 99mTc Nitrido radiopharmaceuticals as imaging agents for tumors.

Authors:  Rui Ding; Yong He; Jingli Xu; Hang Liu; Xiao Wang; Man Feng; Chuanmin Qi; Junbo Zhang
Journal:  Molecules       Date:  2010-11-30       Impact factor: 4.411

8.  Superparamagnetic nanoparticle-catalyzed coupling of 2-amino pyridines/pyrimidines with trans-chalcones.

Authors:  Oanh T K Nguyen; Pha T Ha; Ha V Dang; Yen H Vo; Tung T Nguyen; Nhan T H Le; Nam T S Phan
Journal:  RSC Adv       Date:  2019-02-13       Impact factor: 4.036
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.