| Literature DB >> 15012991 |
Mariona Salvatella1, Gemma Arsequell, Gregorio Valencia, Raquel E Rodríguez.
Abstract
By the coupling of octylamine to the uronic acid function of morphine-3-glucuronide (M3G) a new glycoconjugate (morphine-3-octylglucuronamide, M3GOAM) was prepared. When assayed in both rats and mice up to ng/kg (i.p.) doses none of the animals survived. The aliphatic octyl chain may be the lethal factor since a closely related derivative (M3GNH2), was not toxic and showed similar opioid antagonist properties than naloxone.Entities:
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Year: 2004 PMID： 15012991 DOI： 10.1016/j.bmcl.2003.12.016
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823