OBJECTIVE: The authors describe four types of brain structural change in "normal aging:" cortical atrophy, central atrophy, deep white-matter hyperintensities (DWMH), and periventricular hyperintensities (PVH). Cross-sectional investigations have reported that greater volumes of these forms of "subclinical structural brain disease" (SSBD) were found with increasing age. Greater volumes were also associated with poorer cognition, even though subjects performed within the normal range. The natural history of these forms of SSBD and their functional impact are not well established. METHODS: Twenty-nine normal subjects, ages 60-89, were examined longitudinally by volumetric magnetic resonance imagery, with two assessments performed at least 2 years apart; 26 also completed neuropsychological testing to evaluate processing speed, executive functions, language, and other cognitive functions. Associations between structure and function were evaluated with regression models. RESULTS: For most subjects, the volumes for signs of all types of SSBD were found to have increased; for many subjects, increases were small, and a few showed no change or small decreases. PVH and DWMH increases were predicted by baseline cerebrovascular risk factors. Cognitive test performance changed little over time for these normal subjects. CONCLUSIONS: SSBD volumes increased for most subjects over time, with small average increases for most types. Pretreatment cerebrovascular risk factors were associated with greater increases of PVH and DWMH, suggesting that progression of these types of SSBD may be amenable to intervention.
OBJECTIVE: The authors describe four types of brain structural change in "normal aging:" cortical atrophy, central atrophy, deep white-matter hyperintensities (DWMH), and periventricular hyperintensities (PVH). Cross-sectional investigations have reported that greater volumes of these forms of "subclinical structural brain disease" (SSBD) were found with increasing age. Greater volumes were also associated with poorer cognition, even though subjects performed within the normal range. The natural history of these forms of SSBD and their functional impact are not well established. METHODS: Twenty-nine normal subjects, ages 60-89, were examined longitudinally by volumetric magnetic resonance imagery, with two assessments performed at least 2 years apart; 26 also completed neuropsychological testing to evaluate processing speed, executive functions, language, and other cognitive functions. Associations between structure and function were evaluated with regression models. RESULTS: For most subjects, the volumes for signs of all types of SSBD were found to have increased; for many subjects, increases were small, and a few showed no change or small decreases. PVH and DWMH increases were predicted by baseline cerebrovascular risk factors. Cognitive test performance changed little over time for these normal subjects. CONCLUSIONS: SSBD volumes increased for most subjects over time, with small average increases for most types. Pretreatment cerebrovascular risk factors were associated with greater increases of PVH and DWMH, suggesting that progression of these types of SSBD may be amenable to intervention.
Authors: D M J van den Heuvel; V H ten Dam; A J M de Craen; F Admiraal-Behloul; H Olofsen; E L E M Bollen; J Jolles; H M Murray; G J Blauw; R G J Westendorp; M A van Buchem Journal: J Neurol Neurosurg Psychiatry Date: 2006-02 Impact factor: 10.154
Authors: Joel H Kramer; Dan Mungas; Bruce R Reed; Margaret E Wetzel; Molly M Burnett; Bruce L Miller; Michael W Weiner; Helena C Chui Journal: Neuropsychology Date: 2007-07 Impact factor: 3.295
Authors: Lauren E Salminen; Peter R Schofield; Kerrie D Pierce; Thomas E Conturo; David F Tate; Elizabeth M Lane; Jodi M Heaps; Jacob D Bolzenius; Laurie M Baker; Erbil Akbudak; Robert H Paul Journal: Age (Dordr) Date: 2014-07-01
Authors: Y W Chen; M E Gurol; J Rosand; A Viswanathan; S M Rakich; T R Groover; S M Greenberg; E E Smith Journal: Neurology Date: 2006-07-11 Impact factor: 9.910
Authors: Adolf Pfefferbaum; Torsten Rohlfing; Margaret J Rosenbloom; Weiwei Chu; Ian M Colrain; Edith V Sullivan Journal: Neuroimage Date: 2012-10-12 Impact factor: 6.556