Literature DB >> 15010228

Live Salmonella enterica serovar Typhimurium (S. Typhimurium) elicit dendritic cell responses that differ from those induced by killed S. Typhimurium.

Mari Norimatsu1, Victoria Chance, Gordon Dougan, Christopher J Howard, Bernardo Villarreal-Ramos.   

Abstract

The immune response of bovine monocytes-derived dendritic cells (DC) exposed to either live or killed Salmonella enterica serovar Typhimurium was compared. Both live and killed bacteria induced changes in morphology with distinctive formation of processes and up-regulation of the ability of DC to stimulate allogeneic T-cell proliferation. Also, both live and killed bacteria up-regulated the expression of MHC-I, MHC-II and CD80. However, live bacteria induced greater up-regulation of the expression of CD40 and CD86 than killed bacteria. Live bacteria also induced greater up-regulation of transcription for IL-6, IL-12 and GM-CSF than killed bacteria as measured by quantitative RT-PCR. These data suggest that blood-monocyte-derived DC may follow distinct maturation pathways following exposure to live or killed bacteria. These differences are likely to have consequences for the priming of the adaptive immune responses.

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Year:  2004        PMID： 15010228     DOI： 10.1016/j.vetimm.2003.12.008

Source DB:  PubMed          Journal:  Vet Immunol Immunopathol        ISSN： 0165-2427            Impact factor:   2.046


  8 in total

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Authors:  Lan Hu; Mechelle D Bray; Manuel Osorio; Dennis J Kopecko
Journal:  Infect Immun       Date:  2006-05       Impact factor: 3.441

2.  Protective efficacy of a Salmonella Typhimurium ghost vaccine candidate constructed with a recombinant lysozyme-PMAP36 fusion protein in a murine model.

Authors:  Ja Young Moon; So Young Kim; Won Kyong Kim; Zhili Rao; Jung Hee Park; Ji Young Mun; Boram Kim; Hyo Sun Choi; Jin Hur
Journal:  Can J Vet Res       Date:  2017-10       Impact factor: 1.310

3.  Genetic profiling of dendritic cells exposed to live- or ultraviolet-irradiated Chlamydia muridarum reveals marked differences in CXC chemokine profiles.

Authors:  Michelle L Zaharik; Tarun Nayar; Rick White; Caixia Ma; Bruce A Vallance; Nadine Straka; Xiaozhou Jiang; Jose Rey-Ladino; Caixia Shen; Robert C Brunham
Journal:  Immunology       Date:  2006-10-31       Impact factor: 7.397

4.  Biofilm and planktonic Enterococcus faecalis elicit different responses from host phagocytes in vitro.

Authors:  Kasturee Daw; Arto S Baghdayan; Shanjana Awasthi; Nathan Shankar
Journal:  FEMS Immunol Med Microbiol       Date:  2012-03-08

5.  Protective efficacy of the recombinant lysozyme-PMAP36 fusion protein-inactivated Salmonella Typhimurium vaccine candidate via oral immunization in a murine model.

Authors:  Jayoung Moon; Soyoung Kim; Wonkyong Kim; Zhili Rao; Junghee Park; Byungyong Park; Jin Hur
Journal:  Can J Vet Res       Date:  2020-07       Impact factor: 1.310

6.  Enhancement of immune responses by an attenuated Salmonella enterica serovar Typhimurium strain secreting an Escherichia coli heat-labile enterotoxin B subunit protein as an adjuvant for a live Salmonella vaccine candidate.

Authors:  Jin Hur; John Hwa Lee
Journal:  Clin Vaccine Immunol       Date:  2010-12-15

7.  Capacities of migrating CD1b+ lymph dendritic cells to present Salmonella antigens to naive T cells.

Authors:  Michel Olivier; Benjamin Foret; Yves Le Vern; Laurence A Guilloteau
Journal:  PLoS One       Date:  2012-01-18       Impact factor: 3.240

8.  Differential macrophage function in Brown Swiss and Holstein Friesian cattle.

Authors:  Amanda Jane Gibson; Sally Woodman; Christopher Pennelegion; Robert Patterson; Emma Stuart; Naomi Hosker; Peter Siviter; Chloe Douglas; Jessica Whitehouse; Will Wilkinson; Sherri-Anne Pegg; Bernardo Villarreal-Ramos; Dirk Werling
Journal:  Vet Immunol Immunopathol       Date:  2016-02-28       Impact factor: 2.046
  8 in total

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