| Literature DB >> 15010114 |
Toshiaki Taoka1, Masayuki Fujioka, Yoshiyuki Matsuo, Mitsuru Notoya, Satoru Iwasaki, Akio Fukusumi, Hiroyuki Nakagawa, Masahiko Sakamoto, Kimihiko Kichikawa, Hajime Ohishi.
Abstract
To examine the correlation between tissue water content and signal intensity on fluid-attenuated inversion recovery (FLAIR) images, we analyzed infarcted rat brain, verified the results by theoretical simulation, and compared them with conventional spin-echo images. We produced brain infarction with cavitation in five rats by middle cerebral artery occlusion. After in vivo MRI, histologic sections of the MRI plane were obtained. We measured the signal intensity of regions on FLAIR and spin-echo images, and measured the area of cavitation on histologic sections. We plotted curves of cavity percentage to signal intensity. Theoretical values were calculated using a two-compartment model. On the curve of cavity area to signal intensity, the signal on FLAIR images peaked in tissues with 20% to 30% area of cavitation. On the theoretical curve, the signal on FLAIR images peaked at 90% tissue water content. These results seem to be characteristic of FLAIR.Entities:
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Year: 2004 PMID： 15010114 DOI： 10.1016/j.mri.2003.09.004
Source DB: PubMed Journal: Magn Reson Imaging ISSN： 0730-725X Impact factor: 2.546