Literature DB >> 1500863

Inhibition of tumor growth in vivo with a soluble CD44-immunoglobulin fusion protein.

M S Sy1, Y J Guo, I Stamenkovic.   

Abstract

CD44H is the principal cell surface receptor for hyaluronate, which is a major glycosaminoglycan of the extracellular matrix. Expression of CD44H is enhanced in a variety of malignant tumors and correlates with tumor aggressiveness, supporting the notion that interaction between CD44H and hyaluronate may play an important role in tumor growth and dissemination. In this report we show that in vivo tumor formation by human lymphoma Namalwa cells, stably transfected with CD44H, can be suppressed by a soluble human CD44H-immunoglobulin fusion protein. Disruption of the interaction between CD44H and its physiologic ligands may provide a novel strategy for controlling tumor growth in vivo.

Entities:  

Mesh：

Substances：

Year:  1992        PMID： 1500863      PMCID： PMC2119319          DOI： 10.1084/jem.176.2.623

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  18 in total

Review 1.  Metastatic tumor cell interactions with endothelium, basement membrane and tissue.

Authors:  G L Nicolson
Journal:  Curr Opin Cell Biol       Date:  1989-10       Impact factor: 8.382

2.  A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family.

Authors:  I Stamenkovic; M Amiot; J M Pesando; B Seed
Journal:  Cell       Date:  1989-03-24       Impact factor: 41.582

3.  CD44 is the principal cell surface receptor for hyaluronate.

Authors:  A Aruffo; I Stamenkovic; M Melnick; C B Underhill; B Seed
Journal:  Cell       Date:  1990-06-29       Impact factor: 41.582

4.  Hyaluronate and invasiveness of the rabbit V2 carcinoma.

Authors:  B P Toole; C Biswas; J Gross
Journal:  Proc Natl Acad Sci U S A       Date:  1979-12       Impact factor: 11.205

Review 5.  The pathogenesis of cancer metastasis.

Authors:  G Poste; I J Fidler
Journal:  Nature       Date:  1980-01-10       Impact factor: 49.962

Review 6.  Tumor cell instability, diversification, and progression to the metastatic phenotype: from oncogene to oncofetal expression.

Authors:  G L Nicolson
Journal:  Cancer Res       Date:  1987-03-15       Impact factor: 12.701

Review 7.  Cell adhesion receptor expression during melanoma progression and metastasis.

Authors:  I R Hart; M Birch; J F Marshall
Journal:  Cancer Metastasis Rev       Date:  1991-06       Impact factor: 9.264

Review 8.  The role and regulation of tumour-associated hyaluronan.

Authors:  W Knudson; C Biswas; X Q Li; R E Nemec; B P Toole
Journal:  Ciba Found Symp       Date:  1989

9.  The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells.

Authors:  I Stamenkovic; A Aruffo; M Amiot; B Seed
Journal:  EMBO J       Date:  1991-02       Impact factor: 11.598

10.  Human keratinocytes express a new CD44 core protein (CD44E) as a heparan-sulfate intrinsic membrane proteoglycan with additional exons.

Authors:  T A Brown; T Bouchard; T St John; E Wayner; W G Carter
Journal:  J Cell Biol       Date:  1991-04       Impact factor: 10.539
View more
  27 in total

1.  Identification and characterization of CD44RC, a novel alternatively spliced soluble CD44 isoform that can potentiate the hyaluronan binding activity of cell surface CD44.

Authors:  R K Chiu; C Carpenito; S T Dougherty; G M Hayes; G J Dougherty
Journal:  Neoplasia       Date:  1999-11       Impact factor: 5.715

2.  Pigment epithelium-derived factor binds to hyaluronan. Mapping of a hyaluronan binding site.

Authors:  S Patricia Becerra; L Alberto Perez-Mediavilla; John E Weldon; Silvia Locatelli-Hoops; Preenie Senanayake; Luigi Notari; Vicente Notario; Joe G Hollyfield
Journal:  J Biol Chem       Date:  2008-09-19       Impact factor: 5.157

3.  Structural variability of CD44v molecules and reliability of immunodetection of CD44 isoforms using mAbs specific for CD44 variant exon products.

Authors:  M P Martegani; F Del Prete; A Gasbarri; P G Natali; A Bartolazzi
Journal:  Am J Pathol       Date:  1999-01       Impact factor: 4.307

4.  Proteoglycans in Normal and Healing Skin.

Authors:  Margaret Mary Smith; James Melrose
Journal:  Adv Wound Care (New Rochelle)       Date:  2015-03-01       Impact factor: 4.730

Review 5.  CD44 in inflammation and metastasis.

Authors:  J Lesley; R Hyman; N English; J B Catterall; G A Turner
Journal:  Glycoconj J       Date:  1997-08       Impact factor: 2.916

6.  Human ovarian tumour cells can bind hyaluronic acid via membrane CD44: a possible step in peritoneal metastasis.

Authors:  M J Gardner; J B Catterall; L M Jones; G A Turner
Journal:  Clin Exp Metastasis       Date:  1996-09       Impact factor: 5.150

7.  Activation of CD44, a receptor for extracellular matrix components, protects chronic lymphocytic leukemia cells from spontaneous and drug induced apoptosis through MCL-1.

Authors:  Yair Herishanu; Federica Gibellini; Ndegwa Njuguna; Inbal Hazan-Halevy; Mohammed Farooqui; Sarah Bern; Keyvan Keyvanfar; Elinor Lee; Wyndham Wilson; Adrian Wiestner
Journal:  Leuk Lymphoma       Date:  2011-06-08

8.  In vivo evidence for the role of CD44s in promoting breast cancer metastasis to the liver.

Authors:  Allal Ouhtit; Zakaria Y Abd Elmageed; Mohamed E Abdraboh; Tong F Lioe; Madhwa H G Raj
Journal:  Am J Pathol       Date:  2007-11-08       Impact factor: 4.307

9.  sCD44 internalization in human trabecular meshwork cells.

Authors:  Michael J Nolan; Tomoyo Koga; Loyal Walker; Ryan McCarty; Algis Grybauskas; Michael C Giovingo; Kevin Skuran; Paulius V Kuprys; Paul A Knepper
Journal:  Invest Ophthalmol Vis Sci       Date:  2013-01-17       Impact factor: 4.799

Review 10.  CD44: physiological expression of distinct isoforms as evidence for organ-specific metastasis formation.

Authors:  M Zöller
Journal:  J Mol Med (Berl)       Date:  1995-09       Impact factor: 4.599
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.