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Literature DB >> 15007174

Beta 2-Glycoprotein I binds factor XI and inhibits its activation by thrombin and factor XIIa: loss of inhibition by clipped beta 2-glycoprotein I.

Tong Shi¹, G Michael Iverson, Jian C Qi, Keith A Cockerill, Matthew D Linnik, Pamela Konecny, Steven A Krilis.

Abstract

Activation of factor XI (FXI) by thrombin in vivo plays a role in coagulation by providing an important positive feedback mechanism for additional thrombin generation. FXI is activated in vitro by thrombin, or FXIIa in the presence of dextran sulfate. In this report, we investigated the effect of beta(2)-glycoprotein I (beta(2)GPI) on the activation of FXI. beta(2)GPI bound FXI in vitro and inhibited its activation to FXIa by thrombin and FXIIa. The affinity of the interaction between beta(2)GPI and FXI was equivalent to the interaction between FXI and high molecular weight kininogen. Inhibition of FXI activation occurred with lower concentrations of beta(2)GPI than found in human plasma. Proteolytic clipping of beta(2)GPI by plasmin abolished its inhibition of FXI activation. The results suggest a mechanism of regulation whereby physiological concentrations of beta(2)GPI may attenuate thrombin generation in vivo by inhibition of FXI activation. Plasmin cleavage of beta(2)GPI provides a negative feedback that counteracts its inhibition of FXI activation.

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Year: 2004 PMID： 15007174 PMCID： PMC374348 DOI： 10.1073/pnas.0400281101

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

49 in total

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Authors: J Nimpf; H Wurm; G M Kostner
Journal: Atherosclerosis Date: 1987-02 Impact factor: 5.162

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10. Activation of factor XI in plasma is dependent on factor XII.

Authors: T Brunnée; C La Porta; S R Reddigari; V M Salerno; A P Kaplan; M Silverberg
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18 in total

1. Membrane binding of beta2-glycoprotein I can be described by a two-state reaction model: an atomic force microscopy and surface plasmon resonance study.

Authors: Roland Gamsjaeger; Alexander Johs; Anna Gries; Hermann J Gruber; Christoph Romanin; Ruth Prassl; Peter Hinterdorfer
Journal: Biochem J Date: 2005-08-01 Impact factor: 3.857

2. Interaction of β2-glycoprotein I with lipopolysaccharide leads to Toll-like receptor 4 (TLR4)-dependent activation of macrophages.

Authors: Patrick Laplante; Pascal Amireault; Rebecca Subang; Mélanie Dieudé; Jerrold S Levine; Joyce Rauch
Journal: J Biol Chem Date: 2011-09-29 Impact factor: 5.157

Beta 2-Glycoprotein I binds factor XI and inhibits its activation by thrombin and factor XIIa: loss of inhibition by clipped beta 2-glycoprotein I.

Review 1. The coagulation cascade: initiation, maintenance, and regulation.

2. Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor.

3. Factor XI-dependence of surface- and tissue factor-initiated thrombus propagation in primates.

4. Beta 2-glycoprotein-I (apo-H) inhibits the release reaction of human platelets during ADP-induced aggregation.

5. Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H).

6. Complete nucleotide and deduced amino acid sequence of human beta 2-glycoprotein I.

7. Fibrinogen blocks the autoactivation and thrombin-mediated activation of factor XI on dextran sulfate.

Review 8. Immunology and clinical importance of antiphospholipid antibodies.

9. Activity, disulphide mapping and structural modelling of the fifth domain of human beta 2-glycoprotein I.

10. Activation of factor XI in plasma is dependent on factor XII.

1. Membrane binding of beta2-glycoprotein I can be described by a two-state reaction model: an atomic force microscopy and surface plasmon resonance study.

2. Interaction of β2-glycoprotein I with lipopolysaccharide leads to Toll-like receptor 4 (TLR4)-dependent activation of macrophages.

Review 3. Clinical relevance of β₂-glycoprotein-I plasma levels in antiphospholipid syndrome (APS).

4. Identification of coagulation factor XI as a ligand for platelet apolipoprotein E receptor 2 (ApoER2).

5. Sulfated, low molecular weight lignins inhibit a select group of heparin-binding serine proteases.

6. An A1-A1 mutant with improved binding and inhibition of β2GPI/antibody complexes in antiphospholipid syndrome.

7. Plasmin-cleaved beta-2-glycoprotein 1 is an inhibitor of angiogenesis.

8. beta2-glycoprotein i is a cofactor for tissue plasminogen activator-mediated plasminogen activation.

Review 9. Thiol-Disulfide Exchange Reactions in the Mammalian Extracellular Environment.

10. Feedback activation of factor XI by thrombin does not occur in plasma.