OBJECTIVE: To compare contact lens biomicroscopy with optical coherence tomography (OCT) for the detection of diabetic foveal edema. METHODS: Study participants consisted of a convenient cohort of consecutive patients with diabetes mellitus seen at the Wilmer Eye Institute's Retinal Vascular Center, Baltimore, MD. Case characteristics were recorded and eyes were examined by 1 of 4 retina specialists by means of contact lens biomicroscopy. Edema involving the center of the macula was assessed as definitely present, questionably present, or definitely not present. The OCT testing was performed and interpreted by trained technicians, masked to the physicians' assessment of foveal edema. Agreement between OCT and contact lens examination for the absence or presence of foveal edema was evaluated. RESULTS: One hundred seventy-two eyes of 95 patients with diabetes were enrolled in August and September 2002. Foveal thickness was objectively measured by OCT in 170 (99%) of 172 cases. We found excellent agreement between OCT and contact lens examination for the absence or presence of foveal edema when OCT thickness was normal (<or=200 microm) or moderately to severely increased (>300 microm). However, agreement was poor when foveal thickness was mildly increased on OCT (201-300 microm). CONCLUSIONS: Agreement between contact lens examination and OCT for the detection of diabetic foveal edema is poor when OCT thickening is mild. This suggests that contact lens biomicroscopy is relatively insensitive for the detection of mild foveal thickening apparent on OCT. Additional studies are needed to investigate the natural course of cases with mildly increased foveal thickness on OCT that do not appear thickened clinically.
OBJECTIVE: To compare contact lens biomicroscopy with optical coherence tomography (OCT) for the detection of diabetic foveal edema. METHODS: Study participants consisted of a convenient cohort of consecutive patients with diabetes mellitus seen at the Wilmer Eye Institute's Retinal Vascular Center, Baltimore, MD. Case characteristics were recorded and eyes were examined by 1 of 4 retina specialists by means of contact lens biomicroscopy. Edema involving the center of the macula was assessed as definitely present, questionably present, or definitely not present. The OCT testing was performed and interpreted by trained technicians, masked to the physicians' assessment of foveal edema. Agreement between OCT and contact lens examination for the absence or presence of foveal edema was evaluated. RESULTS: One hundred seventy-two eyes of 95 patients with diabetes were enrolled in August and September 2002. Foveal thickness was objectively measured by OCT in 170 (99%) of 172 cases. We found excellent agreement between OCT and contact lens examination for the absence or presence of foveal edema when OCT thickness was normal (<or=200 microm) or moderately to severely increased (>300 microm). However, agreement was poor when foveal thickness was mildly increased on OCT (201-300 microm). CONCLUSIONS: Agreement between contact lens examination and OCT for the detection of diabetic foveal edema is poor when OCT thickening is mild. This suggests that contact lens biomicroscopy is relatively insensitive for the detection of mild foveal thickening apparent on OCT. Additional studies are needed to investigate the natural course of cases with mildly increased foveal thickness on OCT that do not appear thickened clinically.
Authors: N M Bressler; K M Miller; R W Beck; S B Bressler; A R Glassman; J W Kitchens; M Melia; D K Schlossman Journal: Eye (Lond) Date: 2012-03-23 Impact factor: 3.775
Authors: F D Verbraak; D M de Bruin; M Sulak; L A M S de Jong; M Aalders; D J Faber; T G van Leeuwen Journal: Lasers Med Sci Date: 2005-04-28 Impact factor: 3.161
Authors: Diana V Do; Minhee Cho; Quan Dong Nguyen; Syed Mahmood Shah; James T Handa; Peter A Campochiaro; Ingrid Zimmer-Galler; Jennifer U Sung; Julia A Haller Journal: Trans Am Ophthalmol Soc Date: 2006
Authors: Igor Kozak; Victoria L Morrison; Thomas M Clark; Dirk-Uwe Bartsch; Byung Ro Lee; Iryna Falkenstein; Ajay M Tammewar; Francesca Mojana; William R Freeman Journal: Retina Date: 2008-04 Impact factor: 4.256
Authors: David J Browning; Adam R Glassman; Lloyd P Aiello; Neil M Bressler; Susan B Bressler; Ronald P Danis; Matthew D Davis; Frederick L Ferris; Suber S Huang; Peter K Kaiser; Craig Kollman; Srinavas Sadda; Ingrid U Scott; Haijing Qin Journal: Ophthalmology Date: 2008-08 Impact factor: 12.079