| Literature DB >> 15006402 |
Peter Ettmayer1, Andreas Billich, Thomas Baumruker, Diana Mechtcheriakova, Heide Schmid, Peter Nussbaumer.
Abstract
Fluorescently labeled d-erythro-sphingosines have been successfully synthesized in 9 and 12 steps starting from commercially available Garner aldehyde. Determining the influence of the nature, position and linkage of the label on the in vitro phosphorylation rate by sphingosine kinases 1 and 2 resulted in the identification of a pyrene- and a NBD-labeled sphingosine which are both phosphorylated with efficiency comparable to the natural substrate.Entities:
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Year: 2004 PMID： 15006402 DOI： 10.1016/j.bmcl.2003.12.099
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823